ABSTRACT
Objective: To detect the serum levels of D-dimer and N-terminal pro B-type natriuretic peptide [NT-pro BNP] in patients with Acute Ischemic Stroke [AIS], and to explore the risk factors of AIS
Methods: A total of 246 AIS patients treated in our hospital from January 2015 to January 2017 were selected. Meanwhile, 240 healthy subjects were selected as a control group. The D-dimer and NT-pro BNP levels of the two groups were compared. Correlations of such levels with age, gender, blood lipid, Intima- Media Thickness [IMT], fibrinogen and degree of neurological deficits were analyzed
Results: The AIS group had significantly higher levels of Triglyceride [TG], Low-Density Lipoprotein [LDL], D-dimer, NT-pro BNP and fibrinogen as well as IMT than those of the control group, but the High-Density Lipoprotein [HDL] level of the AIS group was significantly lower [P<0.05]. The patients with different genders and ages had significantly different D-dimer and NT-pro BNP levels [P<0.05]. The D-dimer and NT-pro BNP levels were correlated with gender and age. Such levels of females were significantly higher than those of males [P<0.05]. The D-dimer and NT-pro BNP levels of the >/= 60 years old group significantly exceeded those of the <60 years old group [P<0.05]. The levels of D-dimer and NT-pro BNP were negatively correlated with that of HDL [P<0.05], but positively correlated with TG, LDL and fibrinogen levels, IMT, and National Institutes of Health Stroke Scale score [P<0.05]. Multivariate Logistic regression analysis showed that the OR values of D-dimer and NT-pro BNP were 3.65 and 6.96 respectively
Conclusion: Serum D-dimer and NT-pro BNP levels usually increased in AIS patients, and the levels were significantly correlated with AIS onset