Relationship of chronic hepatitis C with interferon treatment and thyroid diseases / 中华内分泌代谢杂志

The article explores the relationship of the hepatitis C virus infection with interferon treatment and thyroid diseases and reviews the subtypes of the thyroid diseases.Autoimmune and nonautoimmune cases of thyroiditis are often seen in patients with chronic hepatitis C while undergoing interferon treatment,especially in females with positive thyroid autoantibodies.Graves' disease is very rare.The thyroid function may be as a transient thyrotoxicosis,then followed by hypothyroidism.The thyroid function in patients with nonautoimmune thyroiditis is usually easy to recover.

Approach to the patient with primary hypothyroidism accompanied by pituitary hyperplasia and increased serum creatine kinase level / 中华内分泌代谢杂志

Pituitary hyperplasia may be found in patients with primary hypothyroidism as the decreased thyroid hormone level attenuates negative feedback effect.Sometimes the enlarged pituitary may be misdiagnosed as a pituitary tumor.Patients with long term untreated hypothyroidism often have extremely high level of serum creatine kinase and thus may be misdiagnosed as suffering from myositis.In order to increase the awareness of the nonspecific symptoms of primary hypothyroidism,this article introduces the diagnosis and treatment of a patient with primary hypothyroidism with raised serum creatine kinase level and pituitary hyperplasia.

Diagnosis and treatment of Sj(o)gren's syndrome with severe ostalgia as the main clinical manifestation / 中华内分泌代谢杂志

Objective To analyze the clinical characteristics of five Sj(o)gren's syndrome (SS) patients with severe ostalgia. Methods Five SS patients from the endocrinology department of our hospital were retrospectively analyzed. Results All the patients were female, with 9.5 year average course of disease, obvious ostalgia, muscle weakness and complaint, limitation of activity, and different degree of exocrine gland impairment. All the patients had different degree of acidosis, disorders of calcium and phosphorus metabolism, and dyspoiesis of calcitriol. Among them, three patients were found to have hyperinsulinemia and muscle pathological changes detected by the biopsy. Conclusions System factors must be investigated when patients present the bone symptom. At the same time, muscle problem should not be neglected and the patients should be treated as an entirety.