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Acta Universitatis Medicinalis Anhui ; (6): 429-433,441, 2023.
Article in Chinese | WPRIM | ID: wpr-1038489

ABSTRACT

Objective@#To explore the effect and mechanism of lycorine on oxaliplatin ( OXA) induced chemotherapy pain in mice.@*Methods @#40 mice were randomly divided into 4 groups,10 mice per group,which were respectively divided into control group,model group,administration group,and inhibitor group.A mouse model of chemotherapy induced pain was established by intraperitoneal injection of OXA for 5 consecutive days.Intrathecal administration of lycorine was performed.Behavioral changes and expression levels of inflammatory related proteins were detected .@*Results @#Compared with control group,model group mice exhibited the increased number of spontaneous flinches,decreased mechanical nociceptive threshold,decreased movement distance and latency,and up-regulated expression levels of interleukin-1 β (IL-1 β) ,astrocytic marker glial fibrillary acidic protein ( GFAP) ,cyclooxygenase-2( COX-2) ,NOD-like receptor protein 3 ( NLRP3 ) ,cysteinyl aspartate and specific proteinase 1 ( Caspase- 1) .Compared with model group,lycorine administration reduced the number of spontaneous flinches,increased mechanical nociceptive threshold ,enhanced the movement distance and latency ,bound and reduced COX-2 expression,down-regulated the expression levels of IL-1 β , GFAP ,NLRP3 and Caspase-1.@*Conclusion@#Lycorine reduces COX-2 expression,inhibits NLRP3 inflammasome activation,suppresses spinal inflammation,consequently alleviates pain behaviors and improved motor ability of mice.

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