ABSTRACT
OBJECTIVE: To prepare compound lincomycin nasal drops for children and establish a quality control method for this preparation. METHODS: Compound lincomycin nasal drops for children were prepared using lincomycin hydrochloride as main component with its content determined by polarimetry. The content and stability of the preparation within 12mon under room temperature were investigated. Meanwhile irritating test of rabbits' nasal mucosa was conducted. RESULTS: The prepared eye drops were limpid colorless liquid and it met the related standards stated in China Pharmacopeia(2005 edition) in identification as well as tests etc. Lincomycin hydrochloride showed a good linear relation in the range of 3.2～20.0mg?mL-1(r=0.999 9), with average recovery at 100.6%(RSD=0.69%). This preparation showed a little irritation on nasal mucosa, and it was stable within 12mon under room temperature. CONCLUSIONS: This preparation is simple and feasible in preparation technology and controllable in quality.
ABSTRACT
Objective To evaluate the efficacy and safety of Guominjian to infants with eczema. Methods Fifty-seven infants with eczema were randomly divided into the treated group and the control group, who received treatment of Guominjian and usual treatment respectively. Eczema symptoms and change of serum IgE, IL-2, IL-4 was observed before and after treatment. Results After treatment, significant difference was shown between the two groups, significant improvement was shown in the treated group. Conclusion Guominjian is helpful in improving clinical symptoms, reducing corticosteroids use.