A Case of Nasal Septal Abscess Originated from Dentigerous Cyst / 대한이비인후과학회지

Nasal septal abscess can result from various causes such as septal hematoma from septal trauma or hematologic disorder, and infections of surrounding structures like nasal vestibule, upper lip and other oral lesions and hematogenous spread of other infections. Dentigerous cyst is one of the common odontogenic cysts, associated with unerupted teeth, and usually asymptomatic. Symptoms of the dentigerous cyst present mostly oral or maxillomadibular lesions, whereas nasal symptoms of the dentigerous cyst is uncommon. We report an unusual case of dentigerous of a 61 year-old of the dentigerous cyst of mesiodens with nasal septal abscess.

Expression of TGF-beta 1, osteonectin and BMP-4 on bone regeneration in mandibular distraction osteogenesis combination with a compression stimulation

Distraction osteogenesis(DO) is a technique of lengthning bone including soft tissue by gradual separation of surgically divided bone surfaces. Distraction osteogenesis combination with a compression stimulation(DO-CO) was a new technique by authors to enhance new bone quality and to shorten the consolidation period. The purpose of this study was to compare DO with DO combined with compression force in efficiency by evaluating the expression of TGF-beta 1, osteonectin and BMP-4 on bone regenerate in rabbit mandible. Fourty two rabbits were used for this experiment. On the control group, the distraction was carried out at the rate of 1 mm per day to obtain the amount of 8 mm distraction for 8 days. On the experimental group, the distraction was carried out at the rate of 1 mm per day for 10 days, 3 days-latency period, and then the compression was carried out as counter direction 1 mm per day for 2 days. After 0 day, 5 days, 13 days, 20 days, 27 days, 34 days and 41 days, three rabbits on each group were sacrificed and the distracted portion of mandible were cut and treated for RT-PCR observation. The level of expression of TGF-beta 1 and osteonectin were shown more and longer expression in the experimental group than in the control group. The expression of BMP-4 was maintained with high level during the entire experimental period in both groups. These findings suggested that DO with compression stimulation could be a favorable technique for obtaining a good new bone quality.

Impact of methylation of the gene p16(INK4a) on prognosis of head and neck osteosarcoma

PURPOSE: Osteosarcoma occurring in the head and neck region is known as a malignant tumor that shows a relatively poor prognosis and, despite various treatments, clinicians have often been confounded by it. The existence or non-existence of the mutation of the gene p16(INK4a) has been used in prognosis assessment. In this study, author have attempted to determine whether methylation of the gene p16(INK4a) could be applied to forecast the progress of osteosarcomas in the head and neck region having been given poor prognoses in the diagnostic process and the early stage of treatment. RESEARCH SUBJECT AND METHOD: Clinicopathologic investigations, immunohistochemical examinations, a methylation specific polymerase reaction (MSP) analysis, and a survival analysis were conducted on the tissues of 20 patients with mandibulofacial osteosarcoma. RESULTS: Neither age, sex, size, smoking or non-smoking, nor region have showed a statistical significance with methylation or unmethylation of the gene p16(INK4a) and expression rates demonstrated by immunohisto-chemical examinations. A chi-square test indicated that recurrence inclination has no relation with the expression rate of p16 protein (p=0.6615), but it showed a statistical significance with methylation of the gene p16(INK4a) (p=0.0033). With respect to investigations of the survival rates, a Kaplan-Meier survival analysis found that the manifestation rate of p16 protein did not have an impact on survival (p=0.8864), but that the methylation of the gene p16(INK4a) resulted in significant differences in survival rates (p=0.0105). CONCLUSIONS: The above results show that methylation of the gene p16(INK4a) could be one of the major factors that help determine the recurrence inclination and prognosis of osteosarcomas occurring in the head and neck region.