ABSTRACT
Subject(s)
Humans , Cicatrix , Cleft Lip , Hypertrophy , Incidence , Lip , Nose , Surgery, OralABSTRACT
This study was performed to investigate the changes of nerve after the injection of alcohol and glycerol at the infraorbital nerve in rats. Using the eighteen Sprague-Dawley rats, weighing 200-250g, 99% alcohol, pure glycerol, and sterile saline was injected to the epineurium of the infraorbital nerve. Glycerol injected rats were devided into 0.01ml, 0.03ml and 0.05ml groups. The alcohol and control group were injected 0.03ml at the left infraorbital nerve. The following results were obtained by histopathological examination after 1 week, 1 month, and 3 months. A few inflammatory cell infiltration and no signs of nerve degeneration were noted in control group. Total nerve degeneration was noted in the alcohol group and no regeneration was noted in 1month, and partial regeneration was noted at 3month. The nerve degeneration was noted at the periphery of nerve bundle in 0.01ml glycerol injection group. Total degeneration was noted in the 0.03ml and 0.05ml glycerol injection group and the degree was propotional to dose. These results suggest that injection of alcohol and glycerol are effective to nerve blockage by nerve degeneration, and nerve degeneration by glycerol injection is propotional to dose and nerve regeneration by glycerol injection is inversely propotional to dose.
Subject(s)
Animals , Rats , Glycerol , Nerve Degeneration , Nerve Regeneration , Peripheral Nerves , Rats, Sprague-Dawley , RegenerationABSTRACT
Subject(s)
Humans , Cleft Lip , Congenital Abnormalities , Hope , Nose , Prognosis , TransplantsABSTRACT
Subject(s)
Female , Humans , Male , Pregnancy , Abscess , Branchial Region , Branchioma , Clavicle , Diagnostic Errors , Drainage , Epithelium , Fistula , Inflammation , Lymphoid Tissue , Neck , RecurrenceABSTRACT
The purpose of the present study was to investigate the effect of Bioactive glass on bone regeneration in the experimental mandibular bone defects. Five rabbits, weighing about 2.0kg, were used. Three artificial bone defects, 5x5x5mm in size, were made at the inferior border of the mandible. In the experimental group 1, the bone defect was grafted with Biogran and covered with Bio-Gide resorbable membrane. In the experimental group 2, Biogran was grafted only. In the control group, the bone defect was filled with blood clot and was spontaneously healed. The animals were sacrificed at 1, 2, 4, and 8 weeks after the graft. Microscopic examination was performed. Results obtained were as follows: In the control group, the osteoid tissue was observed at week 1 and the bone trabeculi were connected each other and matured at week 2. The lamellar bone formation appeared at week 4, and the amount of bone tissue was increased at week 8. In the experimental group 1, the fibrous tissue was filled between the granules of Bioactive glass and the cartilage formation was found adjacent to the normal bone at week 1. The bone tissue was formed between the granules at week 2, while the amount of bone tissue increased and the lamellar bone formation was observed at week 4. The lamellar bone was increased at week 8. Histologic findings were Similar between the experimental groups 1 and 2, although the amount of Bioactive glass granules lost was increased in the latter. These results suggest that new bone formation is found around the Bioactive glass granules grafted into the bone defects, and the membrane plays a role in keeping the granules and preventing the fibrous tissue invasion.