ABSTRACT
Microbial infections remain a worldwide leading cause of death,despite the evolution of a large number of new antibiotics everyyear. Currently, several bacteria have developed resistanceagainst antibiotics drugs which remain a major issue inantibiotics drug discovery. This review provides detailedinformation about antimicrobial and antifungal agent synthesisbelonging to the pyrazoles scaffold. We reassemble the resultsobtained from several studies to characterize the importance ofheteroatom nuclei in many synthetic products. Additionally,several compounds based on pyrazole derivatives such asbenzimidazole, benzothiazole, indole, acridine, oxadiazole,imidazole, isoxazole, pyrazole, triazole, quinoline and quinazolineincluding other pyrazole containing drugs such as pyridazine,pyridine and pyrimidine are highlighted. Furthermore, you willfind in this review 134 best promise structures collected fromrecent studies, relating the pyrazoles structures to the relevantbiological activities, in particular, antimicrobial and antifungalone.
Subject(s)
Humans , Drug Resistance, Microbial , Nitrogen , Pyrazoles , Acids, Heterocyclic , Document Analysis , Anti-Bacterial AgentsABSTRACT
Les effets pharmacologiques de la 4-phenyl-1;5-benzodiazepin-2-one ont ete examines chez des souris par des tests comportementaux classiques (Test de planche a trous; Test de labyrinthe et Test de la tige tournante) et compares par rapport aux produits dont le potentiel anxiogenique ou anxiolytique sont connus. L'analyse de nos resultats a montre que la 4-phenyl-1;5-benzodiazepin-2-one et le diazepam ont augmente le temps passe dans les bras ouverts; tandis que la picrotoxin a entraine la diminution de ce temps. Considerant les resultats de l'evaluation de l'activite locomotrice; du comportement exploratoire et du comportement des animaux sur la tige tournante; le diazepam et la 4-phenyl-1;5-benzodiazepin-2-one ont influence de facon significative ces derniers par rapport a la picrotoxin et au vehicule. Ces donnees suggerent que la 4-phenyl-1;5- benzodiazepin-2-one possede une activite anxiolytique