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1.
Adv Rheumatol ; 63: 38, 2023. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1505594

ABSTRACT

Abstract Objective To determine prevalence and factors associated with flares post Coronavirus disease 2019 (COVID-19) mRNA vaccination in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and spondyloarthritis (SpA). Methods A retrospective multi-centre study was conducted (January 2021 to February 2022). Data were collected during index visit, defined as first post-vaccine visit in which the patient had a physician-defined flare, or if at least 3 months had elapsed since first vaccine dose, whichever came first. Factors associated with flares were identified using mixed effects Cox regression and expressed as hazard ratio (HR) and 95% confidence interval (CI). Results Total of 2377 patients were included (1563 RA, 415 PsA and 399 SpA). Among patients with RA, PsA and SpA, 21.3%, 24.1% and 21.8% experienced a flare respectively. Of those who experienced a flare, only 10.2%, 11.0% and 14.9% were severe in patients with RA, PsA and SpA respectively. Patients with low or moderate/high disease were more likely to flare compared to those in remission in patients with RA only (HR: 1.68, 95% CI 1.22-2.31; HR: 2.28, 95% CI 1.50-3.48, respectively). Receiving the Moderna vaccine was associated with a higher HR of flare compared to the Pfizer vaccine in patients with PsA only (HR: 2.21, 95% CI 1.20-4.08). Patients who had two vaccine doses were found to be less likely to flare (HR: 0.08, 95% CI 0.06-0.10). HRs of flares were not significantly different among RA, PsA and SpA. Conclusion About one-fifth of patients experienced a disease flare post COVID-19 mRNA vaccination, but most flares were non-severe. Patients with active disease prior to vaccination should be monitored closely for disease flares, especially in patients with RA.

2.
Eng. sanit. ambient ; 9(4): 312-321, out.-dez. 2004. ilus, tab, graf
Article in Portuguese | LILACS | ID: lil-406806

ABSTRACT

O crescimento do contingente populacional das cidades requer o gerenciamento eficiente dos recursos hídricos, particularmente quando a exploração de novas fontes de abastecimento mostra-se dispendiosa e os recursos naturais cada vez mais escassos. Em contrapartida, em diversas cidades brasileiras, são comuns redes de distribuição de água para abastecimento com elevados índices de perdas, sejam elas não-físicas ou físicas (perdas por vazamento). O presente estudo visa avaliar as perdas por vazamentos de um setor da rede de distribuição de água da cidade de Campo Grande-MS. Para tanto, utiliza-se um procedimento iterativo de avaliação hidráulica que considera as perdas por vazamento e a dependência das demandas com a pressão, utilizando o simulador hidráulico EPANET 2 (Rossman, 2000), com vistas à calibração em termos dos parâmetros do modelo de vazamentos, bem como dos coeficientes de perda de carga localizada relativa a componentes hidráulicos presentes na rede. Para a resolução do problema inverso correspondente são utilizados os Algoritmos Genéticos (AGs).


Subject(s)
Leakage , Natural Resources Management , Water Distribution Networks , Water Resources , Water Supply , Calibration , Water Resources Development
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