ABSTRACT
This is a comprehensive review of the work done on the clinical and field application by a team of a new antimalarial nitroquine.A total of 198 acute cases of plasmodium falciparum infection (both chloroquine sensitive and chloroquine-resistant) were treated with nirtoquine-composite 50-70 mg?3d with satisfactory results.The effect of treating 510 acute cases of P.vivax with nitroquine-composite 50 mg?3d was slightly less as compared with routine chloroquine treatment.The prophylactic trials made in 2 chloroquine resistant p.falciparum endemic areas among a total population of 4540 showed that when uitroquine-composite was given in dose of 50 mg/d/15d or 75mg/2d/m gives satisfactory prophylactic effects.Ladoratoty experiments show that nitroquine is effective to the tissue,erythrocytic and sporogonic stages of malaria parasites.A resouable scheme of medicating nitroquine is proposed.