ABSTRACT
Objective To detect plasma concentrations of Calcitonin gene-related peptide (CGRP),endothelin (ET)-1 at different periods after subarachnoid hemorrhage(SAH),and probe the correlation of CGRP,ET-1 and the pathogenesis of cerebral vasospasm after SAH.Mehods Plasma concentrations of CGRP,ET-1 were measured in patients who were diagnosed with SAH (38 cases) at different periods (1-3 d,4-7 d,14-21 d after SAH) by radio-immunity technique.According to the occurrence of cerebral vasospasm,these patients were separated into two groups:vasospasm group(31 cases) and non-vasospasm group(7 cases).Twenty healthy persons after physical examinations were allocated to be control group.Results Compared with control group and nin-vasospasm group,the plasma concentration of CGRP in vasospasm group was obviously lower,especially in the 4-7 d time slot,and ET-1 was obviously higher,especially in the 4-7 d time slot.There were statistical differences among the three groups(P<0.05 or <0.01).Cerebral vasospasm occurred in 2 cases during 1-3 d,in 28 cases during 4-7 d and in l case during 14-2l d after SAH.Conclusions CGRP,ET-1 participate in the pathological process of SAH.The abnormality of vascular endnfhelial construction/diastolic function is correlated with delayed cerebral vasospasm.