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Rapid diagnosis of cytomegalovirus infection in congenital neonates.

Amarapal, P; Tantivanich, S; Pengsa, K; Chotekiate, U; Kaolueng, S; Balachandra, K; Janeprasert, J; Samkosade, R.

Southeast Asian J Trop Med Public Health ; 2001 Mar; 32(1): 154-7

Article in English | IMSEAR | ID: sea-32800

ABSTRACT

Immunostaining was compared with PCR for diagnosis of congenital CMV infection. IgM and IgG antibody assays were also performed in parallel. Immunostaining gave sensitivity and specificity of 60% and 97% respectively. Correlations among immunostaining, PCR and the presence of IgM antibody was reported. Immunostaining can be used for early diagnosis of congenital CMV infection in parallel with detection of IgM antibody.

Subject(s)

Base Sequence , Cytomegalovirus Infections/congenital , DNA Primers , Enzyme-Linked Immunosorbent Assay , HeLa Cells , Humans , Immunoglobulin G/immunology , Immunoglobulin M/immunology , Infant, Newborn , Neonatal Screening , Polymerase Chain Reaction , Sensitivity and Specificity , Thailand

ABSTRACT

Subject(s)

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