ABSTRACT
BACKGROUND– Work output of an employee is dependent on the job satisfaction level and is an important criterion as its effect has an indirect impact on the society. A study on job satisfaction level of faculties in Government Medical Colleges would help in the betterment of the Medical Education System in India as it would bring out factors that affect the performance of medical teachers. METHODS-- 100 structured questionnaires, based on 'The Minnesota Satisfaction Questionnaire', were distributed among faculties, which were duly filled up by the participants and the data from the questionnaires were statistically analyzed. RESULT--According to the grade of satisfaction level, it was found that 4.4% were extremely satisfied, 21.1% were very satisfied , 37.8% were satisfied, 30% were somewhat satisfied, , 5.5% were not satisfied, and 1.2% was indecisive. CONCLUSION—Transfer, low salary, disparity in infrastructure is instigating medical teachers to join different private medical colleges.
ABSTRACT
Background: The increasing incidence of drug resistance in Leishmaniasis necessitates evaluation of combination chemotherapy. Miltefosine and amphotericin B are established anti-leishmanial drugs, while artemisinin has shown significant leishmanicidal activity in experimental models. In this study, we have evaluated the additive/synergistic effect of artemisinin with amphotericin B or miltefosine. Methods: Leishmania parasites were isolated from the bone marrow aspirate of a patient with visceral leishmaniasis. Parasites were typed as Leishmania donovani by restriction fragment length polymorphism of internal transcribed spacer 1 region of Leishmania genome. Promastigotes were incubated in a fixed ratio combination of artemisinin (0-500 μM) and amphotericin B (0-100 nM) or miltefosine (0-100 μM) and cell viability was assessed. An isobologram was constructed to evaluate the additive/synergistic effect, wherein it was considered additive if the mean sum fractional inhibitory concentration (mean ΣFIC) at the IC50 level was <2, but ≥1 and synergism, if the mean ΣFIC was <1. Results: The isobologram showed an additive effect for three combinations of artemisinin-amphotericin B and artemisinin-miltefosine, the mean ΣFICs ranging from 1.02 to 1.44 and 1.08 to 1.33 along with a synergistic effect with one combination, the mean ΣFICs being 0.58 and 0.81 respectively. Conclusions: This study supports the combination use of artemisinin-amphotericin B and artemisinin-miltefosine, worthy of future pharmacological consideration.