ABSTRACT
The aim of this research was to estimate the bioactivity of nano-hydroxyapatite/poly (L-lactic acid) composites in simulated body fluid. In vitro test showed that the pH value of simulated body fluid (SBF) declined gradually and the existence of hydroxyapatite (HA) particles neutralized the acid degradation product of poly (L-lactic acid) (PLLA). Bone-like apatite deposited on the surface, and silkworm-like crystals and plate-like clusters appeared after soaking. At the same time, there were many honeycomb-like pores caused by nano-composite degraded. The results indicated that the hydroxyapatite/poly (L-lactic acid) nano-composites have good bioactivity and degradation characteristics.
Subject(s)
Biocompatible Materials , Bone Substitutes , Chemistry , Durapatite , Chemistry , Lactic Acid , Chemistry , Microscopy, Electron, Scanning , Nanoparticles , Polyesters , Chemistry , Polymers , Chemistry , Porosity , X-Ray DiffractionABSTRACT
<p><b>OBJECTIVE</b>To investigate the mechanisms of the oil-in-oil nanoemulsions transport through the gastrointestinal tract and the transport efficiency changed with its different particle size in the lymphatic channels.</p><p><b>METHOD</b>The behavior of nanoemulsions in vivo and their absorption via lymph after oral administration was investigated, with the transport efficiency and absorption pathway of nanoemulsions clarified by lymph duct cannulation in rats.</p><p><b>RESULT</b>It suggested about 36.8% of puerarin nanoemulsions was transported into systematic circulation via lymph. Nanoparticles with different size absorbed by the lymphatic channels varied as the degree of transportion.</p><p><b>CONCLUSION</b>The degree of absorption and particle transport is inversely proportional to the size.</p>
Subject(s)
Animals , Female , Male , Rats , Absorption , Biological Transport , Emulsions , Isoflavones , Pharmacokinetics , Lymph , Metabolism , Nanoparticles , Particle Size , Rats, Sprague-DawleyABSTRACT
Objective: Extracting ephedrine and berberine from the water extract of Ephedra Herba and Rhizoma Coptidis. Methods: Modified PVA was used as separating membrane and separated alkaloids. Results: A colorless ephedrine aqueous solution was obtained when extraction time was less than 8 hours; while a three constitution solution was obtained when time of extraction is over 8 hours. So is Rhizoma Coptidis. The membrane is hardly fouled. Conclusion: Purity of alkaloids from Herba Ephedra and Rhizoma Coptidis by membrane separation is Superior to that by alcoholic sediment but amount of alkaloids is reverse.