The association between angiotensin I converting enzyme gene polymorphism and Chinese late onset Alzheimer disease / 中华医学遗传学杂志

<p><b>OBJECTIVE</b>To investigate the relationship between angiotensin I converting enzyme gene insertion/deletion polymorphism and Alzheimer disease (AD), as well as the effect of hypertension on the relationship.</p><p><b>METHODS</b>This case-control study, included 96 AD patients meeting the DSM-IV diagnosis, and 96 subjects as controls coming from the same area and in the same environmental condition. Using the polymerase chain reaction (PCR) amplified the DNA segments, and the PCR products were identified by 2% agarose gel and visualized by ethidium bromide staining.</p><p><b>RESULTS</b>There was significant difference between AD patients and controls in ACE genotypes and alleles distribution, as well as between AD patients with high blood pressure and controls with high blood pressure. But between normotensive AD patients and normotensive controls, there was no significant difference in ACE genotypes distribution (P>0.05).</p><p><b>CONCLUSION</b>ACE genotypes associated with the risk of AD, but II genotype as risk genetic factor only restricted in subjects with high blood pressure.</p>

Neuropsychological and Functional Study in Screening Alzheimer Disease in Henan Province / 中国心理卫生杂志

Objective:to do neuropsychological tests and apply functional questionnaire in screening of Alzheimer disease in rural area of north China. Method: subjects positive in screening with MMSE were applied a battery of neuropsychological tests including Fuld Object Memory test (FOM), a categorical test (Animal Naming Test), Digit Span Subtest from WAIS-R, and Block Design Subtest from WISC-III. Examination of apraxia and Pfeffer Functional Questionnaire were also applied.Result:There were significant differences of FOM in different groups, such as Alzheimer disease (AD) group, vascular dementia (VD) group, depression group, and VD+AD group. FOM had better sensitivity and specificity, while the sensitivities of RVR and apraxia were low, and the specificity of Digital Span and Block Design were not high enough.Conclusion:FOM may play an important role in diagnosis of Alzheimer disease.