ABSTRACT
Objective To explore clinical efficacy and safety of Wutou-Chishizhi decoction combined with conventional medicinefor treatment for ischemic cardiomyopathy and heart failure. Methods A total of 103 patients with ischemic cardiomyopathy and heart failure were divided into control group (n=51) and treatment group (n=52). Patients of control group were treated with conventional medicine, while treatment groupwere treated Wutou-Chishizhi decoction combined with conventional medicine. The two groups were treated for 28 days. Clinical curative effect was evaluated after treatment. The score of quality of life of the two groups were compared. The LVEDD, LVESD, LVEF, VEGF, hs-CRP, BNP and cTNⅠ of the two groups were compared. The adverse reactions of the two groups during the treatment were compared. Results Total effective rate of the treatment group was 94.23％(49/52), which was significantly higher than the control group 76.47％ (39/51), and the difference was statistically significant (χ2=6.527, P=0.011). After treatment, the LVEDD (50.25 ± 6.82 mm vs. 57.12 ± 7.33mm, t=4.926) and LVESD (44.13 ± 3.63 mm vs. 46.20 ± 4.05 mm, t=2.733) in the treatment group were significantly lower than those in the control group (P<0.05). The LVEF (45.57％ ± 7.30％ vs. 41.14％ ± 6.22％, t=3.312) in the treatment group was significantly higher than that in the control group (P<0.05). After treatment, the VEGF in the treatment group was significantly higher than that in the control group (P<0.05). And the hs-CRP (2.11 ± 0.41 mg/L vs. 3.05 ± 0.63 mg/L, t=8.992), BNP (82.02 ± 21.13 pg/L vs. 122.35 ± 30.52 pg/L, t=7.810) and cTNⅠ (0.25 ± 0.08 μg/L vs. 0.37 ± 0.10 μg/L, t=6.732) in the treatment group were significantly lower than those in the control group (P<0.05). There were no serious adverse reactions of the two groups during treatment. Conclusions The Wutou-Chishizhi decoction combined with conventional medicine for treatment of ischemic cardiomyopathy and heart failure has a good efficacy and low adverse reactions, can improve the cardiac function and quality of life, reduce the serum hs-CRP, BNP and cTNⅠ levels, improve the serum VEGF level, and it was worthy clinical application.