Synergistic anti-inflammatory effect of NSAIDs plus B vitamins administered pre and postoperatively in third molar surgery: randomized clinical trial / Efeito anti-inflamatório sinérgico da associação de AINEs e vitaminas do complexo B administrada no pré e pós-operatório de cirurgia de terceiros molares: ensaio clínico randomizado

Objective : The aim of the present study was to evaluate the synergistic anti-inflammatory effect of Non-steroidal anti-inflammatory drugs (NSAIDs) plus B vitamins administered pre and postoperatively in surgeries of impacted mandibular third molars. Material and Methods : Double-blind randomized clinical trial, sixty-six patients participated and were randomized into 2 groups. The control group was administered meloxicam 15 mg intramuscularly plus placebo orally and to the experimental group, meloxicam 15 mg intramuscularly plus vitamins B [B1, B6, and B12] orally; both treatments were administered preoperatively. The anti-inflammatory effect was evaluated by pain intensity, facial swelling (facial contour measurements), and mouth opening (distance between the upper and lower incisors) during the post-surgical phase. Student's t-test was performed for independent samples. Results : In all the evaluated times (1 hour, 6 hours, 12 hours, 24 hours, 2 days, and 3 days after the end of the surgery) the experimental group presented a significantly lower intensity of pain compared to the control group (p<0.05). The highest pain intensity was recorded at 6 hours (17.7 ± 9.1 mm in the experimental group and 34.5 ± 21.3 mm in the control group). Swelling and mouth opening were similar in both groups, at all times evaluated (p>0.05). Conclusion : In the present study, the administration of NSAIDs plus B vitamins (B1, B6, B12) produced lower intensity of pain compared to the administration of only NSAIDs. Nevertheless, swelling and mouth opening were similar in all evaluations for both study groups (AU)

Objetivo : O objetivo do presente estudo foi avaliar o efeito anti-inflamatório sinérgico de anti-inflamatórios não esteroidais (AINEs) com vitaminas do complexo B administrados no pré e pós-operatório de cirurgias de terceiros molares inferiores impactados. Material e Métodos: Ensaio clínico randomizado duplo-cego, 66 participantesque foram randomizados em 2 grupos. O grupo controle recebeu Meloxicam 15 mg por via intramuscular + placebo por via oral e o grupo experimental, Meloxicam 15 mg por via intramuscular + vitaminas B [B1, B6 e B12] por via oral; ambos os tratamentos foram administrados no pré-operatório. O efeito anti-inflamatório foi avaliado pela intensidade da dor, edema facial (medidas do contorno facial) e abertura da boca (distância entre os incisivos superiores e inferiores) durante a fase pós-cirúrgica. Foi aplicado o teste t de Student para amostras independentes. Resultados: Em todos os tempos avaliados (1 hora, 6 horas, 12 horas, 24 horas, 2 dias e 3 dias após o término da cirurgia) o grupo experimental apresentou uma intensidade de dor significativamente menor em relação ao grupo controle (p <0,05). A maior intensidade de dor foi registrada em 6 horas (17,7 ± 9,1 mm no grupo experimental e 34,5 ± 21,3 mm no grupo controle). Edema e abertura bucal foram semelhantes nos dois grupos, em todos os momentos avaliados (p>0,05). Conclusão: No presente estudo, a administração de AINEs com vitaminas do complexo B (B1, B6, B12) resultou em menor intensidade de dor em comparação com a administração apenas de AINEs. No entanto, o edema e a abertura da boca foram semelhantes em todas as avaliações para ambos os grupos de estudo (AU).

Eficacia de la administración temprana de glucocorticoides en la supervivencia de cobayos (Cavia porcellus) sometidos a un modelo experimental de anafilaxis / Efficiency of the early administration of glucocorticoids in the survival of guinea pigs (Cavia porcellus) submitted to an experimental model of anaphylaxis

Objetivo principal: Demostrar que la administración temprana de glucocorticoides es más eficaz que la tardía para prolongar la supervivencia de cobayos ("Cavia porcelius") sometidos a un modelo experimental de anafilaxis. Diseño: Estudio pre-clínico. Lugar: Facultad de Medicina de la Universidad Nacional Mayor de San Marcos, Lima-Perú. Material biológico: 70 cobayos ("Cavia porcellus"). Intervenciones: La anafilaxis fue inducida por histamina administrada por nebulización, asignándose 4 grupos: T0 (sin tratamiento: 10 cobayos), T1 (tratamiento convencional: 20 cobayos), T2 (administración temprana de glucocorticoides: 20 cobayos) y T3 (administración tardía de glucocorticoides: 20 cobayos). Principales medidas de resultados: Tiempo de supervivencia, número de cobayos vivos, funciones vitales y características histopatológicas. Resultados: Los cobayos del grupo T2 tuvieron un tiempo de supervivencia significativamente más prolongado en comparación a los cobayos de los otros grupos (p<0.05). En el grupo T2 se evidenció un significativo mayor número de cobayos vivos en las evaluaciones realizadas al 3er, 5to y 7mo día posteriores a la inducción de anafilaxis en comparación a los cobayos de los otros grupos (p<0.05). Los valores de las funciones vitales de los cobayos del grupo T2 fueron significativamente superiores, durante el primer día y durante la primera semana, en comparación a los cobayos de los otros grupos (p<0.05). En todas las características histopatológicas evaluadas se observaron significativamente menos alteraciones en el grupo T2 en comparación a los cobayos de los otros grupos. Conclusión: La administración temprana de glucocorticoides es más eficaz que la tardía para prolongar la supervivencia de cobayos ("Cavia porcellus") sometidos a un modelo experimental de anafilaxis.

Main objective: Demonstrate that the early administration of glucocorticoids is more effective than a late one in order to extend the survival of guinea pigs ("Cavia porcellus") subjected to an experimental model of anaphylaxis. Design: Pre clinical study. Place: Faculty of Medicine of the Universidad Nacional Mayor de San Marcos, Lima-Peru. Biological material: 70 guinea pigs ("Cavia porcellus"). Interventions: the anaphylaxis was induced by administering histamine trough nebulization, allocating 4 groups: T0 (without treatment: 10 guinea pigs), T1 (conventional treatment: 20 guinea pigs), T2 (early administration of glucocorticoids: 20 guinea pigs) and T3 (late administration of glucocorticoids: 20 guinea pigs). Main measurement of results: time of survival, number of live guinea pigs, vital functions and histopatological features. Results: the guinea pigs from the T2 group had a significantly longer time of survival in comparison with the guinea pigs from the other groups (p<0.05). In the T2 group, a significantly greater number of live guinea pigs was evident at the 3rd, 5th and 7th day after the induction of anaphylaxis, in comparison with the guinea pigs from the other groups (p<0.05). The values of the vital functions of the guinea pigs from the T2 group were significantly higher, during the first day and during the first week, in comparison with the guinea pigs from the other groups (p<0.05). In all the evaluated histopatological features, significantly fewer alterations were found in the T2 group in comparison with the guinea pigs from the other groups. Conclusion: The early administration of glucocorticoids is more effective than the late one in arder to extend the survival of guinea pigs ("Cavia porcellus") subjected to an experimental model of anaphylaxis.