ABSTRACT
Asthma is characterized by chronic inflammation, goblet cell hyperplasia, the aberrant production of the Th2 cytokines, and eosinophil infiltration into the lungs. In this study, we examined the effects of baicalein, wogonin, and Scutellaria baicalensis ethanol extract on ovalbumin (OVA)-induced asthma by evaluating Th1/Th2 cytokine levels, histopathologic analysis, and compound 48/80-induced systemic anaphylaxis and mast cell activation, focusing on the histamine release from rat peritoneal mast cells. Baicalein, wogonin, and S. baicalensis ethanol extract also decreased the number of inflammatory cells especially eosinophils and downregulated peribronchial and perivascular inflammation in the lungs of mice challenged by OVA. Baicalein, wogonin, and S. baicalensis ethanol extract significantly reduced the levels of tumor necrosis factor α, interleukin (IL)-1β, IL-4, IL-5 and the production of OVA-specific IgE and IgG1, and upregulated the level of interferon-γ and OVA-specific IgG2a. In addition, oral administration of baicalein, wogonin, and S. baicalensis ethanol extract inhibited compound 48/80-induced systemic anaphylaxis and plasma histamine release in mice. Moreover, baicalein, wogonin, and S. baicalensis ethanol extract suppressed compound 48/80-induced mast cell degranulation and histamine release from rat peritoneal mast cells. Conclusively, baicalein and wogonin as major flavonoids of S. baicalensis may have therapeutic potential for allergic asthma through modulation of Th1/Th2 cytokine imbalance and histamine release from mast cells.
Subject(s)
Animals , Mice , Rats , Administration, Oral , Anaphylaxis , Asthma , Cytokines , Eosinophils , Ethanol , Flavonoids , Goblet Cells , Histamine Release , Histamine , Hyperplasia , Immunoglobulin E , Immunoglobulin G , Inflammation , Interleukin-4 , Interleukin-5 , Interleukins , Lung , Mast Cells , Ovalbumin , Ovum , Plasma , Scutellaria baicalensis , Scutellaria , Tumor Necrosis Factor-alphaABSTRACT
@# Rehabilitation for the elderly is a way to improve the elderly with their ability of daily living and the quality of life,and the Assessment of the ability should be indispensable process to rehabilitation.This paper would introduce the tools that used for evaluating ability of basic activities of daily living(BADL) and ability of instrumental activities of daily living(IADL),as well as how to choose these tools,how to choose facilities for rehabilitation,how to make rehabilitation program,the problems should be pay attention to,the project of exercise and so on.
ABSTRACT
@# ObjectiveTo discuss the main point of rehabilitation treatment on old patients with stroke at restoration stage.Methods26 cases in hospital patients were performed a 8-week (5 days/week) rehabilitation program. Before and after rehabilitation treatment evaluations of locomotion function, muscle tone, range of movement of joints, ability of balance, ambulation and activities of daily living for affected limbs were performed and compared each other. Resultse grade of function and muscle tone of affected limbs had no distinct changes, while the locomotion function and ability of activities of daily living improved significantly(P<0.01). Conclusions Rehabilitation treatment for old patients with stroke at restoration stage is different from the acute stage. In the former case it is focused on facilitating the potential function, while in the latter it is emphasized on preventing and curing disuse syndrome and improving maladaptive behaviors.
ABSTRACT
@#ObjectiveTo study neural protective effect of combined medication with nimodipine and mannitol on injury of cerebral ischemia-reperfusion for screening the better medication method in acute cerebral ischemia-reperfusion. MethodsA model of cerebral ischemia-reperfusion was performed by clipping bilateral common carotid artery of rats with vago- and releasing them 3 hours later. 40 Wistar female rats within 1 month were divided into 5 groups randomly with 8 rats each: model group (no use of medicine), nimodipine group(0.2mg/kg), mannitol group(0.5g/kg), nimodipine and mannitol group, sham-operated group (no use of medicine and no clipping process). The changes of SOD and MDA in brain tissue were measured 24 hours after cerebral ischmic reperfusion in all groups. At the same time pathologic study was performed to compare the different groups.ResultsThere were significant differences between nimodipine and mannitol group and other groups in changes of SOD, MDA and pathological changes(P<0.01). Conclusions Combined medication with nimodipine and mannitol is the better way to protect brain tissue from acute cerebral ischemia-reperfusion than other way in present experiment, by synergistic action.