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1.
Chinese Journal of Pathology ; (12): 298-301, 2009.
Article in Chinese | WPRIM | ID: wpr-319742

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the clinicopathological characteristics, diagnosis and differential diagnoses of proximal-type epithelioid sarcoma (PES).</p><p><b>METHODS</b>Five cases of PES were retrieved from pathology files. Clinical, pathologic and immunohistochemical features of the tumors were reviewed.</p><p><b>RESULTS</b>One patient was female and 4 were male. Ages of the patients ranged from 19 to 46 years. The sites of the tumor involvement were vulvar (2 cases), hypogastric zone (1 case), anterosuperior iliac spine (1 case) and buttock (1 case). Clinically, the tumor masses were painless and progressive solitary nodules. Microscopically, the tumor cell growth was infiltrative in nature, nodular in appearance with degenerative and necrotic cells at the central areas. The tumors consisted of relatively uniform epithelioid cells with round or oval nuclei and eosinophilic cytoplasm. Immunohistochemically, the tumor cells were positive for vimentin (5/5), CK (4/5), EMA (4/5), beta-catenin (3/5), CD34 (3/5), and S-100 protein (1/5), but were negative for SMA, MyoD1, Desmin, HMB-45, CK7 and CK20.</p><p><b>CONCLUSION</b>Definitive diagnosis of PES relies on its histopathological characteristics in conjunction with appropriate immunohistochemical findings.</p>


Subject(s)
Adult , Female , Humans , Male , Middle Aged , Young Adult , Chemotherapy, Adjuvant , Epithelioid Cells , Metabolism , Pathology , Follow-Up Studies , Mucin-1 , Metabolism , Neoplasm Recurrence, Local , Pelvic Neoplasms , Metabolism , Pathology , General Surgery , Radiotherapy, Adjuvant , Sarcoma , Metabolism , Pathology , General Surgery , Soft Tissue Neoplasms , Metabolism , Pathology , General Surgery , Vimentin , Metabolism , Vulvar Neoplasms , Metabolism , Pathology , General Surgery , beta Catenin , Metabolism
2.
National Journal of Andrology ; (12): 810-814, 2008.
Article in Chinese | WPRIM | ID: wpr-309789

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the clinical pathological characteristics, diagnosis and differential diagnosis of Paget's disease of the scrotum and penis.</p><p><b>METHODS</b>Thirteen cases of Paget's disease of the scrotum and penis were analyzed by light microscopy, alcian-blue (AB)/periodic-acid-Schiff (PAS) and immunohistochemical staining.</p><p><b>RESULTS</b>Paget's disease of the scrotum and penis mainly affected old individuals aged 55-84 (mean 71) years. Macroscopically, typical presentations of Paget's disease of the scrotum and penis were eczematoid lesions. Microscopically, Paget cells were distributed singly or in groups (as strands, nests or glandular patterns) within the epidermis. Paget cells were typically stained for AB/PAS, positive for CK7, CEA and EMA, and negative for CK5/6, S-100 and P63. The positive rates of GCDFP-15 and CK20 expressions were 76.92% (10/13)and 53.85% (7/13) respectively.</p><p><b>CONCLUSION</b>Paget's disease of the scrotum and penis is a low-malignancy cutaneous tumor with typical clinical and pathological features. Pathologic diagnosis is based on immunohistochemical findings.</p>


Subject(s)
Aged , Aged, 80 and over , Humans , Male , Middle Aged , Immunohistochemistry , Paget Disease, Extramammary , Pathology , Penile Neoplasms , Pathology , Penis , Pathology , Scrotum , Pathology
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