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Objective To explore the clinical characteristics and treatment strategy for pyoderma gangrenosum (PG). MethodsClinical data of 15 PG patients (from Jan. 1995 to Dec. 2011) in Peking University Third Hospital were retrospectively analyzed, and its clinical characteristics and therapy were studied. ResultsThere were 15 PG patients, including 11(73.3%) males and 4(26.7%) females. In 15 patients, 8(53.3%) had the complication of systemic diseases, the ulcer area was 2.8%(0.5%-7.0%) of total body surface area (TBSA) before treatment and 1.2%(0.6%-2.0%) after treatment, and 7(46.7%) did not have the complication of systemic diseases, the ulcer area was 1.6%(1.0%-3.5%) TBSA before treatment and 0.4%(0.1%-0.9%) after treatment. The differences of ulcer area between patients with and without systemic diseases before and after treatment were both statistically significant (P<0.05). Two of them have the complication of myelodysplastic syndrome, whose ulcer areas were larger than 5% of their whole body areas. One of them has effective response to surgical intervention in his stable stage. Conclusions PG is more common in male, and is prone to have the complication of systemic disease, especially myelodysplastic syndrome, which is often accompanied by large ulcer area. The surgical intervention should be forbidden in its progressive stage. The prognosis is remarkably improved by surgical intervention of local ulcer surface on the basis of systemic treatment when the disease is in its stable period.
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the efficacy, adverse reaction and prognosis of liquid nitrogen freezing combined with 5-aminolaevulinic acid-photodynamic therapy (ALA-PDT) in the treatment of condyloma acuminatum in men.</p><p><b>METHODS</b>We collected medical histories and conducted physical examinations for 35 male patients with condyloma acuminatum in the outpatient department, and treated them by liquid nitrogen freezing combined with ALA-PDT every 7-10 days. We recorded the skin lesions and adverse events each time and followed up the patients at 4 and 24 weeks after treatment.</p><p><b>RESULTS</b>The 35 patients were aged 17-71 (median 31) years, and their average course of disease was 30-180 (mean 60) days. The skin lesion area was reduced remarkably after 3 times of liquid nitrogen freezing combined with ALA-PDT, 16-140 (median 38) mm2 for the first time, 6-63 (median 13) mm2 for the second, and 0-10 (median 3) mm2 for the third, with statistically significant differences (P < 0.01). Two cases (5.7%) relapsed at 4 weeks and 4 cases (11.4% ) at 24 weeks.</p><p><b>CONCLUSION</b>Liquid nitrogen freezing combined with ALA-PDT is better than either liquid nitrogen freezing or ALA-PDT alone for the treatment of condyloma acuminatum in men.</p>
Subject(s)
Adolescent , Adult , Aged , Humans , Male , Middle Aged , Young Adult , Aminolevulinic Acid , Therapeutic Uses , Condylomata Acuminata , Therapeutics , Cryotherapy , Photochemotherapy , PrognosisABSTRACT
Objective To explore the effect of Renzhu Jianwei Granules(Granule of Semen Coicis and Rhizoma Atractylodis Macro- cephalae for strengthening the stomach)on the patients with precancerous lesions of gastric cancer(PLGC)and its mechanism. Methods The 58 patients of chronic atrophic gastritis(CAG)complicated with intestinal metaplasia(IM)and/or dysplasia(Dys) were randomized into treatment group and control group with 29 in each.The treatment group was administered Renzhu Jianwei Gran- ules while the control group was given Weifuchun Tablets.The numbers of positive cells of carcinoembryonic antigen(CEA)and cy- clooxygenase 2(COX-2)of gastric mueosa before and after treatment were observed.Results The scores of positive cells of CEA and COX-2 of gastric mucosa of both groups were greatly reduced after treatment(P0.05).Conclusion Renzhu Jianwei Granules can reduce CEA and COX-2 of PLGC patients,possibly being one of the mechanisms in treating PLGC.