ABSTRACT
To investigate the mechanism of the treatment of hyperlipidemia rats induced by Huangqi San. The 40 male SD rats were randomly divided into normal group, model group, Huangqi San low and high dose group (1, 2 g·kg⁻¹), and positive lipitor group (2 mg·kg⁻¹). The normal group feeds on base feed, and other groups feed on high-fat feed. After 8 weeks, the hyperlipidemia model was successful. After intervention by drugs for 13 weeks, fasting blood glucose, total cholesterol, triglycerides and LDL cholesterol content of all rats were measured. The pathological changes of liver and skeletal muscle of rats were observed in rats. Real-time PCR and Western blot were used to detect the mRNA and protein expression levels of AMPK signaling pathway in the liver and skeletal muscles (AMPK, ACC, CPT1A, SREBP2, HMGCR). The degree of FPG, TC, TG and LDL-C were the highest in the model group, and the liver and skeletal muscle pathology were the most obvious. After intervention by Huangqi San and lipitor, a significant reduction in the blood sugar blood fat, liver, and skeletal muscle injury has improved significantly, except SREBF2 and HMGCR mRNA and protein expression of this enzyme is reduced, other AMPK pathway related mRNA and protein expression increased significantly. Huangqi San effect is superior to lipitor. Huangqi San may improve hyperlipidemia by regulating the AMPK signaling pathway, increasing the oxidation of fatty acids and inhibiting cholesterol synthesis.
ABSTRACT
<p><b>OBJECTIVE</b>To understand correlative elements of post stroke depression (PSD).</p><p><b>METHODS</b>Record scores of the Hamilton Rating Scale for Depression (HRSD) for each PSD patient. Assess the degree of neurological deficit by the modified Scandinavian Stroke Scale (MSSS). Then analyze the correlativity of the patient's HRSD with MSSS, and the relation of PSD with the location and course of lesion.</p><p><b>CONCLUSION</b>The depression degrees in PSD are positively correlated with the degree of neurological deficit post stroke; PSD is not related with the lesion location; the left-handers who hurt in the right hemisphere of the brain has a higher morbidity than that in the left hemisphere.</p>