ABSTRACT
Objective:To evaluate the effect of M-POSSUM and NRS2002 in predicting the postoperative complications and mortality of abdominal surgery in general surgery.Methods:The M-POSSUM score and NRS2002 score of 121 patients undergoing abdominal major surgery in Department of general surgery were measured by continuous fixed-point sampling,and the receiver operating characteristic (ROC) curve was compared between the two methods.The levels of serum albumin,prealbumin and complications were recorded 1,3 and 7 days after operation.Results:The scores of M-POSSUM and NRS2002 in the complication group were significantly higher than those in the non complication group.The difference was statistically significant (P＜0.05).The scores of M-POSSUM and NRS2002 in the death group were significantly higher than those in the survival group(P＜0.05).The area under curve(AUC) of M-POSSUM,NRS2002 score and the combination of the two methods were 0.795,0.714 and 0.826 respectively.The AUC for predicting mortality were 0.904,0.871,and 0.935,respectively.Albumin and prealbumin were significantly lower than those before operation on 1 day,3 day and 7 day(P＜0.05).The values of albumin and prealbumin in the patients without complications increased significantly on the 7 day after surgery(P＜0.05).There was no significant difference between the patients with complications and the 3 days after operation(P＞0.05).Conclusion:M-POSSUM score and NRS2002 score can effectively predict the complications and mortality after general surgery.Patients with major abdominal surgery have higher nutritional risk,and albumin and prealbumin are significantly lower than those before operation,suggesting that the incidence of complications may increase.
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the myocardial damage and changes of myocardial mitochondrial Mn-superoxide dismutase (Mn-SOD) activity in craniocerebral injured rats and the effect of Ginkgo biloba extract (GBE) on them.</p><p><b>METHODS</b>Craniocerebral injured rats model was established by fluid-percussion and treated with GBE. The dynamical changes of electrocardiograph (ECG) in 24 h were monitored, the serum level of MB isoenzyme of creatine kinase (CK-MB) and the change of myocardial mitochondrial Mn-SOD activity as well as the pathologic changes of myocardium (HE staining) were observed.</p><p><b>RESULTS</b>The occurrence of ECG abnormality obviously increased in the injured rats, accompanied with increased serum CK-MB (P<0.05) and decreased myocardial Mn-SOD levels (P<0.05), and the Mn-SOD activity was negatively correlated with the level of CK-MB (r=-0.997, P<0.05). Pretreatment of GBE resulted in the decrease of ECG abnormality occurrence (P<0.01), serum CK-MB level (P<0.05), and degree of myocardial damage, as well as the increase of Mn-SOD activity in post-craniocerebral injured rats.</p><p><b>CONCLUSIONS</b>Craniocerebral injury can result in distinct myocardial damage, which is possibly correlated with the lowering of anti-oxidation stress level of myocardial cellular mitochondria. GBE possesses the protective effect on myocardial damage after craniocerebral injury.</p>