ABSTRACT
Low-power laser(LPL) delivers a small amount of energy without elevation of tissue temperature. LPL has been reported to have biostimulation effects including anti-inflammatory, analgesic, regenerative, immunocorrective, and vasodilative effects. However, the effect of LPL on hair growth has rarely been studied. We investigated the effect of LPL on hair growth in the mouse. After depilation of back skin of mice, we classified the mice into 4 groups: control, laser irradiated group, MoandMore(R) applied group, and Spella 707(R) applied group. Laser irradiation or application of these drugs were performed on the back skin of the mice for 30 days. The results are summarized as follows. Hair growth of control was first observed at 13 days after depilation, and complete hair regrowth was observed at 25 days. Hair growth of both laser irradiation group and MoandMore(R) applied group was first observed at 9 days after depilation, and complete hair regrowth was observed at 20 days. Hair growth of Spella 707(R) applied group was firstly observed at the 9 days after depilation, and complete hair regrowth was observed at the 15 days. Hair growth started at the irradiation site in the laser irradiation group, but it started at the random sites in other groups. In conclusion LPL irradiation have a stimulating effect on the hair growth in the mouse.
Subject(s)
Animals , Mice , Hair Removal , Hair , SkinABSTRACT
Photodynamic therapy (PDT) is a treatment modality involving the use of a photosensitizing agent, oxygen, and light of a specific wavelength to produce selective cell death. PDT has been reported to be useful in treating nonmelanoma skin cancers and a variety of benign skin conditions. We treated condyloma acuminata on the vulvar area with topical PDT using 5-aminolevulinic acid (ALA) and a 632nm diode laser. After two treatment sessions the lesion was completely cleared. The light intensity was 100mW/cm2, and the light dose was 50 and 60J/cm2 respectively. Topical PDT may be a safe and effective treatment modality for condyloma acuminata.