ABSTRACT
Object To study the condition of Wenpi Decoction (WPD) with being decocted first and later added medicinal materials. Methods Contents of aconitine and free anthraquinone in WPD were determined by HPCE. Results Aconitine could reach the safe limit after Radix Aconiti Preparata being decocted 30 min first and the content of free anthraquinone was the highest after Radix et Rhizomea Rhei being decocted 10 min later. Conclusion Radix Aconiti Preparata should be decocted first and Radix et Rhizomea Rhei should be decocted later in WPD.
ABSTRACT
Objective: To select the optimum alcohol concentration of Shangtong Tincture. Methods: The percutaneous absorption test was performed on excised rats skin in improved Franz diffusion cell. The penetrative amount of paeonol was determined quantitatively by HPLC and the content of paeonol as a marker. Results: The penetrative amount of paeonol of Shangtong Tincture with 60%～80% alcohol concentration have a optimal value, the average rate is 0.010mg/cm 2?h. Conclusion: Shangtong Tincture with 70% alcohol concentration is the best.