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Objective: To investigate the effect of low molecular weight heparin sodium combined with magnesium sulfate in the treatment of patients with severe preeclampsia
Study Design: An experimental study
Place and Duration Of Study: The Department of Obstetrics and Gynecology, The Affiliated Hospital, North China University of Science and Technology, from April 2016 to July 2017
Methodology: Patients with severe preeclampsia were randomly divided into observation group [52 cases] and control group [51 cases]. In the control group, magnesium sulfate were used, but in observation group low molecular weight heparin sodium were added. After treatment of 7 days, serum TGF-beta1, VCAM-1, ES levels and endothelial function markers of NO and ET-1 changes were compared between the two groups.The delivery status after treatment was observed in both groups
Results: After treatment of 7 days, serum TGF-beta1 and NO levels in the observation group were higher than those in control group [both p<0.001], and VCAM-1, ES, ET-1, ET-1/NO levels in observation group were lower than those in control group [all p<0.001]. Among the patients who delivered live births, observation group had a longer delivery gestation age after treatment than that of control group [p=0.038]; placental quality, body mass and 1 minute Apgar score of surviving newborns in observation group were all higher than those in control group [all p<0.001]
Conclusion: Low molecular weight heparin sodium combined with magnesium sulfate may improve the prognosis of neonates by reducing the infiltration ability of cytotrophoblasts and regulating endothelial cell function
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Objective To explore the clinical significance of combined detection of homocysteine (Hcy) and myocardial enzyme spectrum in premature infants with asphyxia ,and provide scientific basis for differential diagnosis and treatment of hyperbilirubi‐nemia in premature infants .Methods A total of 150 cases of premature infants with hyperbilirubinemia hospitalized in this hospital from January 2011 to May 2014 were selected and divided into the mild asphyxia group and server asphyxia group .Other 100 cases of premature infants with physiologic jaundice were selected as the control group .Serum levels of total bilirubin(TBIL) ,homocys‐teine(Hcy) and indicators of myocardial enzyme spectrum were detected and comparatively analysed .Results The levels of TBIL , Hcy and indicators of myocardial enzyme spectrum in the mild asphyxia group and server asphyxia group were higher than those in the control group ,had statistically significant differences(P<0 .05) .Combined with the clinical data and the detection results of col‐or Doppler ultrasound ,3 cases of premature infants with asphyxia complicated with hyperbilirubinemia were diagnosed as myocardi‐tis ,29 cases were diagnosed as subclinical myocarditis and 46 cases were diagnosed as suspected myocarditis .Conclusion Different degrees of myocardial cell damage exists in premature infants with hyperbilirubinemia ,and routine determination of Hcy and myo‐cardial enzyme spectrum have positive significance for clinical diagnosis of neonatal myocarditis and subclinical myocarditis .
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Objective To investigate the relationship between hepatitis B virus (HBV) genotype and liver function. Methods The method of microboard nucleate molecular hybridization was employed to detect the genotype in 93 HBV patients of different clinical types and the function of liver. Results Among the 93 HBV patients of different clinical types, there were 24 cases of genotype B (25.81%), 59 cases of genotype C (63.44%), 5 cases of genotype D (5.38%), and 5 cases of mixed type (3 cases of B/D, 2 cases of C/D, 5.38%). Therefore, genotype C took up the largest proportion, followed by genotype B, and then D and mixed genotypes, but there was no genotype A, E or F. The detection rate of genotype C increased according to the sequence of chronic hepatitis B, subacute severe hepatitis and hepatocirrhosis while the detection rate of genotype B decreased gradually. However, the detection rate of genotype C in hepatocellar carcinoma did not rise correspondingly. The levels of ALT, AST and TBIL of genotype C were higher than those of genotype B, but the level of ALB in genotype C was lower than that of genotype B. None of the differences had significance. Conclusion Most of HBV genotypes in Xi'an were C, some of them were B, D and mixed genotypes, but no genotype A, E or F was detected. Except hepatocellar carcinoma, the detection rate of genotype C rose according to the severity of clinical type.
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0.05). The positive rate of HBeAg in genotype C(69.7%) was significantly higher than that in genotype B(42%) (P
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Objective To investigate the clinical significance of serum ferritin level(SF),serum iron(SI) level in patients with chronic hepatitic B.Methods SF was measured by radioimmunoassay,serum iron was measured through atomic absorption spectrometry.Results Chronic HBV infectors mostly had high level of SF and SI,with severity of illness state increasing,especially in the group of severe hepatitis.The levels of SF and SI correlated with HBV duplication to a certain extent and specifically SF and SI increased with the increase of virus duplication.However,it had no statistical significance.Among the sufferers of hepatocirrhosis,numerical values of SF and SI turned to increase with the rank of Child-Pugh(A,B and C) and SF had the correlation with LN(the index of hepatic fibrosis).Patients of hepatocirrhosis with a high SF level had higher frequency of complications occurrence and reoccurrence,the clinical post-cure effects were worse.Conclusion SF and SI can be reference index in forecasting the degree of disease state,hepatic fibrosis and clinical post-cure.