ABSTRACT
Objective:To investigate the safety and effectiveness of dot matrix laser combined with transdermal administration in the treatment of hypertrophic scars.Methods:From January 2014 to December 2019, 123 patients with hypertrophic scars in the Dermatology Clinic, the Second Affiliated Hospital of Anhui Medical University. Observation group included 63 cases, 30 males and 33 females, aged 7 to 69 (31.7±14.6) years; given lomatasone cream for topical application, once in the morning and evening, combined with lattice laser transdermal administration, once a week for 3 months. There were 60 patients in the control group, 28 males and 32 females, aged 10-71 (32.8±15.1) years; topical lomidasone cream was given, one morning and one evening, with a course of 3 months.Results:Clinical trials were completed in 123 patients. The total effective rate in the observation group was 66.7% (42/63), of which 18 cases were cured, and 18 cases were markedly effective; 6 cases were effective, 21 cases were ineffective; the total effective rate in the control group was 20.0% (12/60), of which 0 cases were cured, and the effect was 7 Cases, and 5 cases were effective, 48 cases were ineffective. The effective rate of the observation group was significantly better than that of the control group ( P<0.05), and there were no adverse reactions in the observation group. Conclusions:Lattice laser transdermal administration combined with halomethasone cream for topical treatment of hypertrophic scars is effective, safe, and worthy of clinical application.
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Objective To evaluate the rate of depression in adult rheumatoid arthritis (RA) patients in China.Methods Literature search was conducted to collect studies on the prevalence of depression in adult RA patients in Cochrane library, Medline, EMbase, China National Knowledge Internet (CNKI),China Biology Medicine (CBM), Chinese science & technology journal database (VIP) and Wanfang database.Data were analyzed by R 3.2.0 software after evaluating all data.Results A total of 25 studies, including a total size of 4 830 and 2 712 patients of depression, were eligible for inclusion in the review.The prevalence of depression by analyzing the effect size was 44.7％ [95％CI (37.5％, 52.0％)], which was close to the median of 43.0％ from all studies included and higher than the global rate 38.8％ [95％CI (34％, 43％)].Eight studies, including the sample size of 1 028 cases, 311 cases of mild depressive disorders and 219 cases of moderate or severe depressive disorders, reported the prevalence levels of 30.2％ [30.2％CI (22.1％, 40.0％)] and 16.5％ [95％CI (9.6％,26.9％)], respectively.Subgroup analysis showed that the depression rate of female RA patients was higher than male, the depression rate in the central and western areas were higher than that of the eastern region, the prevalence level estimated by the Geriatric Depression Scale (GDS) was higher than estimated by other tools.Sensitivity analysis showed that the pooled effect size had good stability and reliability.Conclusion The prevalence rate of depression in adult RA patients is 44.7％, suggesting that medical staff should pay much attention to depression in adult RA patients.
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Objective To analyze the clinic features and hereditary characteristics of three subtypes of porokeratosis, namely disseminated superficial actinic porokeratosis (DSAP), porokeratosis palmaris et plantaris disseminata(PPPD) and porokeratosis of Mibelli (PM) in five pedigrees with porokeratosis. Meth-ods After clinical and pathological diagnosis, every living family member of the five pedigrees with poro-kerotosis was undergoing medical examination and genetics analysis. These five pedigrees consisted of three DSAP pedigrees (totally 266 family members including 100 patients), and one PPPD pedigree (composing of 90 members including 26 patients), one PM pedigree (cornposing of 34 members including 17 patients). Results While diagnosed as porokeratosis, the five pedigrees included three distinctive variants, each with its own clinic characteristics. The lesions was initiated on the face in DSAP subtype, on palms and the flex-ion side of fingers in PPPD subtype; or involving sun-covered areas in PM subtype. Of the three subtypes of porokeratosis, the onset age in DSAP subtype was earliest, usually about 8-20 years old, about 14-20 years old in PPPD subtype, but PM subtype about 20-30 years old. Conclusions As a group of autosomal dominant genodermatosis, porokeratosis presented various clinic variants with different genetic basis. And, different subtype could be seen in a same patient or same pedigree.
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Objective To evaluate of the clinical efficacy and side-effect of 595nm tunable pulsed dye laser in treatment of children heamangioma of skin. Methods A retrospective study was conducted according to 76 children patients with heamangioma of skin (including 53 cases of nevus flammenus, 20 strawberry hemangioma and 3 cavernous hemangioma) treated with 595nm tunable pulsed dye laser. We evaluated the efficacy and side-effect of the treatment. Results The effectiveness rates were 83.2% and 86.63%, respectively, in nevus flammenus and strawberry hemangioma, but there were disappointed efficacy obtained in patients with cavernous hemangioma treated with 595nm tunable pulsed dye laser. There was 7.9% of the side-effect rate in the children with heamangioma of skin treated by 595 nm tunable pulsed dye laser. Conclusion There is satisfactory clinical efficacy and lower side-effect for children hemangioma treated by 595nm tunable pulsed dye laser.