ABSTRACT
Objective:To investigate the daily diet and living habits of Hashimoto's thyroiditis (HT) patients, and to explore the influencing factors of HT.Methods:The patients admitted to the Thyroid Surgery Clinic of Cancer Hospital Affiliated to Harbin Medical University from March to December 2021 were selected as the investigation subjects and were divided into observation group (106 patients with HT) and control group (63 healthy people). Questionnaire was used to collect the information of daily diet and living habits of the two groups, and physical examination was used to collect the information of height and weight. The levels of serum thyroid function indicators thyroid stimulating hormone (TSH), free triiodothyronine (FT 3) and free thyroxin (FT 4) were tested by automatic chemiluminescence immunoassay, and the comparison and analysis were conducted between the two groups. Multivariate logistic regression was used to analyze the influencing factors of HT. Results:The results of univariate analysis showed that there were significant differences in sex ratio and serum TSH levels between the two groups ( P < 0.05); the proportion of people in observation group who slept for less than 6 hours per day, frequently looked at their mobile phones, ate fried food ≥1 time per week, and ate meat ≥1 kg per week was higher than that in control group; however, the proportion of people in observation group who drank tea ≥1 time per week, smoked ≥1 time per week, had a salty daily taste, ate nuts ≥1 time per week, and ate vegetables ≥1 kg per week was lower than that in control group, and the differences were statistically significant ( P < 0.05). The results of multivariate logistic regression analysis showed that female, slept duration < 6 hours/day, weekly meat consumption ≥1 kg, and elevated serum TSH levels were risk factors for the onset of HT [odds ratios ( OR) = 3.37, 4.11, 2.48, 1.14, and 95% confidence intervals ( CI): 1.08 - 10.55, 1.46 - 11.59, 1.00 - 6.51, 1.00 - 1.30]; eating ≥1 kg of vegetables per week was a protective factor for the onset of HT ( OR = 0.36, 95% CI: 0.17 - 0.79). Conclusion:Female, poor diet and lifestyle habits are risk factors for the onset of HT.
ABSTRACT
Objective To study the risk factors of central lymph node (CLN) metastasis in papillary thyroid carcinoma (PTC),to provide the basis for clinical treatment.Methods A total of 407 patients with PTC in thyroid surgery,the Third Affiliated Hospital of Harbin Medical University from January 2010 to June 2012 who had undergone at least ipsilateral CLN were studied.These factors included normal situation,thyroidglobulin antibody or thyroid microsomal antibody,family history,pathological features (the size of primary,tumor multifocal,tumor location and capsular invasion),TNM staging and CLN metastasis.Univariate analysis and multivariate analysis were performed using x2 test and binary Logistic regression test,respectively.Results The CLN metastasis rate was 51.351％ (209/407) of the 407 patients with PTC.The CLN metastasis was significantly associated with age,tumor multifocal,the size of primary tumor,capsular invasion and TNM (x2 =21.080,14.974,47.671,12.858,8.765,all P ＜ 0.01).Sex,thyroid globulin antibody or thyroid microsomal antibody,family history and tumor location were not associated with CLN metastasis (x2 =1.457,1.106,0.000,0.260,all P ＞ 0.05).Multivariate analysis indicated that age (＜ 45 year),the size of primary tumor (≥ 1.0 cm),tumor-muhifocal,and TNM (T3 + T4) were the independent risk factors for CLN metastasis [odds ratio (OR) =0.937,2.347,0.380,0.389,all P ＜ 0.01].Conclusions Age (＜ 45 year),the size of primary tumor (≥ 1.0 cm),tumor-multifocal and TNM (T3 + T4) are risk factors for CLN metastasis in PTC.Dissection of CLN should be considered for PTC patients with these factors.
ABSTRACT
Objective To investigate the relationship between ultrasonographic features of papillary thy-roid carcinoma(PTC)and lateral cervical lymph node metastasis (LCLNM).Methods A total of 449 eligible ca-ses with 633 PTC nodules was selected and divided into two groups:LCLNM group included 135 nodules(91 pa-tients);Without metastatic groups included 498 nodules(135 patients).Ultrasonographic features of PTC nodules and the relationship with LCLNM were analyzed by χ2 test and logistic regression analysis .Results In univariate analysis,the significant factors were male,age1 cm),multi-microcal-cificaltion(d<2 mm),mixed flow,wider than tall,CCLNM,extrathyroid extension,located in upper(P<0.05 or P<0.017).Multivariate analysis showed that multi -microcalcificaltion(d<2 mm),wider than tall,CCLNM,ex-trathyroid extension,located in upper pole were predictive factors of LCLNM (P<0.005,OR=1.626,2.644, 0.479,2.579).Conclusion High-frequency ultrasound can accurately describe the sonographic appearance of thyroid nodules;it can be used to remind the risk of LCLNM before operation ,and will be informative for the treat-ment of surgery .
ABSTRACT
@#Objective To prepare the acellular carotid artery of adult pig using biotic enzymes for small-diameter vascular tissue-engineering scaffold.Methods Carotid artery of adult pig was removed cells by using Trypsin/EDTA,ribonuclease and desoxyribonuclease.Residual cellular composition was studied with quantitative DNA analysis and the Hematoxylin and Eosin(H&E)staining.Extracellular matrix composition was evaluated with elastin van Gieson's(VG)staining and scanning electron microscopy(SEM).Results Quantitative DNA analysis and H&E staining confirmed that carotid arteries were completely decellularized.Elastin van Gieson's staining demonstrated that elastin morphology appeared unchanged.Scanning electron microscopy examination of the acellular scaffolds revealed a well-oriented porous decellularized structure that maintained natural architecture of the aorta.Conclusion Carotid artery of adult pig rendered acellular with Trypsin/EDTA,ribonuclease and desoxyribonuclease has well-preserved extracellular matrix for vascular scaffold,which can be used as a scaffold for further small-diameter vascular tissue engineering.
ABSTRACT
@#Migraine headache causes significant burdens for both the individual and society.The pathogenesis of migraine is incompletely understood until now.The clinical therapies mainly include medical treatment,surgical treatment,behavior therapy,acupuncture and so on.However,drug treatment could only relieve symptom temporary and bring many side effects for long term use including nausea,vomiting.Surgical therapy maybe becomes an efficient method for migraine headache.The authors have reviewed the pathogenesis of migraine,anatomical basis for surgical therapy and clinical application in this article.