ABSTRACT
Reconstructed rebalanced hemostasis exists in patients with liver cirrhosis, while such balance is unstable and can be easily broken by stress factors, which may lead to bleeding or thrombosis. There is a lack of effective strategies to prevent and solve the disrupted balance in clinic due to the complex pathogenesis of rebalanced hemostasis, limited testing methods, and insufficient awareness among clinicians. With reference to the articles in recent years, this article summarizes the mechanism of rebalanced hemostasis in liver cirrhosis and the causes of bleeding and thrombosis and discuss the association between blood transfusion and rebalanced hemostasis and the selection of anticoagulant drugs during thrombosis, in order to provide a theoretical basis and new ideas for solving related issues in clinical practice.
ABSTRACT
Objective To explore the prothrombotic state of patients with ulcerative colitis(UC) and the relationship with phase,severity and Truelove classification.Methods 97 patients with UC were grouped by non-active phase and active phase;The latter were subdivided into mild,moderate and severe degree by clinical manifestation and TrueloveⅠ,Ⅱ,Ⅲ via endoscopy,vWF activity,fibrinogen and D-dimer were detected in all patients.Results vWF activity,fibrinogen and D-dimer were markedly higher in active phase than in non-active phase(t=14.137,3.435,3.625,respectively).There were no significant difference in vWF activity,fibrinogen and D-dimer between mild,moderate and severe degree and Truelove Ⅰ,Ⅱ,Ⅲ.Conclusion Prothrombotic state including hypercoagulation and secondary fibrinolysis correlates with the clinical phase of UC significantly.