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1.
Bol. Asoc. Méd. P. R ; 82(5): 197-9, maio 1990. tab
Article in English | LILACS | ID: lil-92365

ABSTRACT

Nine pediatric patients with aplastic or hypoplastic anemia were seen at the Pediatric Hematology-Oncology service of the University of Puerto Rico, from 1980 to first trimester of 1987. Included were eitht males and one female ranging from twenty months to sixteen 8/12 years (mean 13 years). Hematomas and fever were the most common complaints. The interval since the first symptoms and the diagnosis varied from one day to one week. The peripheral cell count was abnormal in all patients; pancytopenia being the most common finding. Five of seven who received antithymocyte globulin (ATG-AM), showed improvement in their peripheral count. The median time interval from the end of ATG-AM and response was two months (range 2 weeks to 15 months)


Subject(s)
Humans , Infant , Child, Preschool , Child , Adolescent , Male , Female , Anemia, Aplastic/therapy , Anemia, Aplastic/blood , Schools, Medical , Hospital Units , Pediatrics , Puerto Rico , Time Factors
2.
P. R. health sci. j ; 6(1): 13-5, Apr. 1987. tab
Article in Spanish | LILACS | ID: lil-66492

ABSTRACT

Para minimizar la toxicidad renal y hematológica durante terapia empírica de antibióticos a pacientes pediátricos con fiebre y neutropenia, la combinación de piperacillin y gentamicina fue evaluada. Veinte episodios de fiebre y neutropenia en pacientes pediátricos (menores de 20 años) con malignidades fueron estudiados. La eligibilidad de los pacientes fue definida como haber tenido fiebre documentada (temperatura de 38.5-C) un número absoluto de neutrófilos menor de 500/mm. Los antibióticos fueron administrados hasta resolverse la neurtropenia y evidenciar mejória clínica. No hubo episodios hemorrágicos, toxicidad renal, hematológica o de otra naturaleza antribuibles a la terapia con antibióticos en los casos estudiados. Los organismos identificados fueron sensitivos a uno o ambos antibióticos. Hubo mejoria clínica y respuesta bacteriológica en todos los casos


Subject(s)
Child, Preschool , Child , Adolescent , Humans , Agranulocytosis/complications , Bacterial Infections/drug therapy , Neoplasms/complications , Neutropenia/complications , Piperacillin/therapeutic use , Bacterial Infections/etiology , Drug Administration Schedule , Drug Therapy, Combination , Gentamicins/administration & dosage , Piperacillin/administration & dosage , Prospective Studies
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