ABSTRACT
A prospective study of the clinico-pathological features of prostate cancer at the time of needle biopsy diagnosis was conducted in the Department of Pathology at the University Hospital of the West Indies over a one-year period. Ninety cases were diagnosed during this time. The mean age of patients at diagnosis was 72 years and the mean Gleason score of the biopsy, 7.3. Serum prostate-specific antigen levels were markedly elevated in the majority of patients, with a mean value of at least 159.8 ng/ml in the 76 patients for whom this information was available. The significance of these findings and that of other histopathological features examined are discussed, particularly in relation to recognized prognostic factors. It is concluded that the diagnosis of prostate cancer in Jamaica appears to be considerably later than that seen elsewhere. This information should provide support for those who advocate the introduction of a vigorous screening process for prostate cancer in Jamaica.
Subject(s)
Aged , Humans , Male , Middle Aged , Prostate-Specific Antigen/blood , Prostatic Neoplasms/pathology , Aged, 80 and over , Prospective Studies , Jamaica , Biopsy, Needle , Hospitals, University , Prostatic Neoplasms/blood , PrognosisABSTRACT
A 10-year review of the files of the Department of Pathology revealed 11 cases of nodular fasciitis. The clinicopathologic features of these cases are presented together with a discussion of the pathology of this lesion. The purpose of this study is to enhance both physicians' and pathologists' awareness of this entity.
Subject(s)
Adult , Female , Humans , Male , Fasciitis , Retrospective Studies , Fascia , Fasciitis , West Indies/epidemiologyABSTRACT
Aortic dissection was confirmed in 33 patients at autopsy at the University Hospital of the West Indies between 1975 and 1988. Twenty-five cases were acute and 8 chronic and the diagnosis was made ante-mortem in 5 cases overall. The high risk of rupture of proximal dissections involving the ascending aorta into the pericardial sac is clear, and the overriding importance of systemic hypertension is once again confirmed. An unusual finding was the higher proportion of females to males. A higher index of suspicion should permit an antemortem diagnosis and appropriate therapy in a larger proportion of patients
Subject(s)
Humans , Adult , Middle Aged , Male , Female , Aortic Aneurysm/pathology , Aortic Dissection/pathology , Sex Ratio , Hypertension/complicationsABSTRACT
We herein describe two cases of Meckel-Gruber Syndrome identified in stilborn infants. Both had all three elements of the classical triad, namely, occipital encephalocele, renal cystic dysplasia and post-axial polydactyly. In addition, many of the other well-known accompanying abnormalities were present. Awareness of this entity in this region is important because of its high risk of recurrence in subsequent pregnancies
Subject(s)
Humans , Pregnancy , Infant, Newborn , Infant , Female , Encephalocele/genetics , Fingers/abnormalities , Polycystic Kidney Diseases/genetics , Encephalocele/diagnosis , Encephalocele/pathology , Fetal Death , Polycystic Kidney Diseases/diagnosis , Polycystic Kidney Diseases/pathology , Genetic Counseling , Diagnosis, DifferentialABSTRACT
Thirty cases of infective endocarditis identified in the autopsy of the University Hospital over a 10-year period are reviewed. The mean age of the patients was 30.6 years, and 70%) were below the age of 40 years. Sixty per cent of the cases had previous heart disease of which rheumatic heart disease was the most common. Degenerative heart disease and floppy mitral valve contributed one case each. The mitral valve was most commonly affected, and there were only 2 cases of right-sided endocarditis. Evidence of systemic embolization was present in 83% of the patients. The results of this stuy are compared with others from both developed and under-developed countries
Subject(s)
Child, Preschool , Child , Adolescent , Adult , Middle Aged , Humans , Male , Female , Endocarditis, Bacterial/epidemiology , Endocarditis, Bacterial/complications , Jamaica , Rheumatic Heart Disease/complications , Rheumatic Heart Disease/epidemiology , Age Factors , Hospitals, University , Developing CountriesABSTRACT
An endodermal sinus tumour of the anterior mediatinum is described in a19-year-old man. This very rare condition is reported for the first time in the Caribbean literature
Subject(s)
Adult , Humans , Male , Mediastinal Neoplasms/diagnosis , Mesonephroma/diagnosis , Combined Modality Therapy , Mediastinal Neoplasms/pathology , Mediastinal Neoplasms/therapy , Mesonephroma/pathology , Mesonephroma/therapy , PrognosisABSTRACT
Two cases of amnion rupture sequence resulting in grossly malformed stillborn infants are described. One baby had marked craniofacial defects while the other had a combination of craniofacial, abdominal wall and limb abnormalities. These are the first such cases to be reported in the English-speaking Caribbean; and aspects of the aetiology, pathogenesis, clinical and pathological features are discussed