ABSTRACT
ABSTRACT Trimethoprim-sulfamethoxazole (TMP-SMX) is the primary therapeutic option for Pneumocystis jirovecii pneumonia (PCP). Gastrointestinal symptoms and cutaneous rash are common side effects, with hyperkalemia being uncommon in patients without kidney dysfunction, and myelotoxicity being even rarer. We present the case of a male patient with hypertension and a recent diagnosis of non-Hodgkin lymphoma, undergoing rituximab treatment for two months. He was admitted to the intensive care unit due to dyspnea, tachypnea, and pleuritic pain, requiring mechanical ventilation. Chest computed tomography showed bilateral and multilobed ground-glass opacities, compromising more than 80% of the lung parenchyma. Pulmonary tuberculosis and COVID-19 were ruled out. An angiotomography and Doppler ultrasound revealed an extensive pulmonary thrombus and deep venous thrombosis. Empiric treatment with TMP-SMX for PCP was initiated, but within four days, the patient experienced metabolic acidosis and severe hyperkalemia, necessitating hemodialysis. He also presented with progressive pancytopenia and critical levels of leukopenia and thrombocytopenia. The hypothesis of TMP-SMX-induced myelotoxicity was suspected. Considering the unavailability of an alternative treatment, it was opted to continue TMP-SMX and initiate a granulocyte-colony-stimulating factor. However, the patient maintained medullary deterioration, becoming refractory to the transfusion of blood derivates. On the 17th day of treatment, a clinical decision was made to suspend TMP-SMX, leading to improvements within 48 hours in marrow and kidney functions, metabolic acidosis, and hyperkalemia. Despite all efforts, the patient died after 35 days of hospitalization due to hospital-acquired infections. This case highlights the importance of clinicians recognizing potential myelotoxicity with TMP-SMX and promptly discontinuing the drug if necessary.
ABSTRACT
Resumo Este artigo tem como objetivo analisar as novas formas de mal-estar que surgem na contemporaneidade, bem como pensar o papel atualmente exercido pelas empresas na constituição das subjetividades. Utilizamos como eixo teórico principal as contribuições da filosofia e da psicologia existencial, articulando-as aos estudos da psicossociologia. As nossas conclusões são no sentido de que a tematização da nossa condição existencial de sermos-para-a-morte coloca em questão o projeto de um sujeito sem limites e onipotente, que impera nos modos de subjetivação dominantes da sociedade capitalista. Ao mesmo tempo, nos permite uma apropriação mais ampla da nossa existência, abrindo um espaço para a experiência da autenticidade.
Abstract This article aims to analyse the new ways of dicontents that appear in the contemporaneousness, besides to think the role fullfilled nowdays by the enterprises in the constitution of subjectivities. We used as a main theoretical base the contributions of existential philosophy and existential psychology, that are related to the psychosociology studies. Our conclusions are that the thematization of our existential condition of being-for-death calls into question the project of a subject without limits and omnipotent, which prevails in the dominant subjectivation modes of capitalist society. At the same time, it allows for a broader appropriation of our existence, opening a space for the experience of authenticity.