ABSTRACT
Objective To investigate the effect of morphine combined with noninvasive positive pressure ventilation in the treatment of patients with acute left heart failure .Methods 80 patients with acute left heart failure were enrolled ,and they were randomly divided into two groups according to the digital table method ,40 cases in each group.The patients in the control group were treated with noninvasive positive pressure mechanical ventilation .The patients in the observation group were treated with morphine sedation on the basis of the treatment of the control gorup.The vital signs test indicators,disease-related parameters,clinical events,cognitive function and quality of life were compared between the the two groups .Results The systolic blood pressure,heart rate,respiratory rate,PaCO2 and myocardial oxygen consumption in the observation group were significantly lower than those in the control group at 30min after treatment,PaO2 and pH in the observation group were significantly higher than those in the control group , the APACHEⅡ,BNP,Hs-cTnl and CK levels in the observation group at 24 h after treatment were significantly lower than those in the control group,the differences were statistically significant (t =8.349,13.127,7.413,17.072, 15.334,2.631,3.088,12.371,8.061,4.784,18.931,6.568,9.464,all P<0.01).The rate of tracheal intubation of the observation group was significantly lower than that of the control group (0.0％vs.20.0％),the rate of withdrawal of the observation group was significantly higher than that of the control group (85.0％ vs.50.0％),the differences were statistically significant (χ2 =6.806,11.168,all P<0.01).The MLHFQ score of the observation group 3 months after treatment was significantly lower than that in the control group [( 24.69 ±5.38)points vs.( 38.24 ± 8.03)points],the difference was statistically significant (t=8.866,P<0.01).There was no statistically significant difference in MoCA score after treatment between the two groups [(24.80 ±2.93)points vs.(25.07 ±2.33)points, t=0.456,P>0.05].Conclusion Morphine has significant influence on the effect of noninvasive positive pressure mechanical ventilation in patients with acute left heart failure .
ABSTRACT
Objective To explore gene polymorphism of the C/T genotype of rs 16 944 in the promoter of IL-1β gene in male population living in the coastal area of Shandong,and thus to investigate the relationship between the gene polymorphism of IL-1β and gout.Methods A total of 276 gout patients and 268 healthy controls were enrolled.The possible association between the polymorphism of IL-1β-511 C/T and gout in Chinese was investigated and gcnotype frequencies and allelic frequencies were calculated by polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) method.Hardy-Weinberg was used to verify the representativeness of the sample.Comparisons between the groups were performed with x2 test and t-test.Results There was no statistically difference in IL-1β-511 C/T genotype frequencies between gout patients and controls(x2=3.251,P=0.197,df=2).The allele frequencies of C and T in gout cases were not different from those in the controls (x2=2.941,P=0.086,OR=1.232,95％CI:0.971-1.563).Moreover,no association between IL-1β-511C/T genotypes and risk factors for gout were observed in gout cases by x2 test.Conclusion Results of the present study suggest that the C/T genotype of rs 16944 in the promoter of IL-1β gene is not associated with gout in male population living in the coastal area of Shandong.