ABSTRACT
We report a middle-aged woman who presented with postpartum acute severe central abdominal pain. Portal vein, thrombosis was diagnosed by ultrasonography and confirmed by splenoportogram. She received thrombolytic therapy with symptomatic improvement and gradual disappearance of the thrombus on ultrasound. Early thrombolytic therapy seems to be effective in the treatment of acute portal vein thrombosis.
Subject(s)
Adult , Female , Fibrinolytic Agents/therapeutic use , Humans , Portal Vein , Streptokinase/therapeutic use , Thrombolytic Therapy , Thrombosis/drug therapyABSTRACT
Clinical evaluation, upper gastrointestinal endoscopy and electron microscopy of mucosal biopsies from antrum, body and fundus of stomach were performed in three control subjects and 17 habitual tobacco chewers. Electron microscopic abnormalities such as discontinuous, fragmented basement membrane with reduction in hemidesmosomes, and widened intercellular spaces filled with clusters of desmosomes were found in the gastric mucosa of habitual tobacco chewers; these were similar to those reported in experimental carcinogenesis and leukoplakia. It is concluded that habitual chewing of tobacco produces electron microscopic alterations in the human gastric mucosa which may be important precursors for gastric malignancy.
Subject(s)
Adult , Gastric Mucosa/ultrastructure , Humans , Microscopy, Electron , Plants, Toxic , Tobacco, SmokelessABSTRACT
Seventeen chronic tobacco chewers and three control subjects underwent clinical evaluation, upper gastrointestinal endoscopy and esophageal mucosal biopsies. The esophageal biopsies were processed and examined under the electron microscope. A large number of ultrastructural abnormalities such as discontinuous, fragmented basement membrane, with reduction in hemidesmosomes, widened intercellular spaces were found in the esophageal mucosa of chronic tobacco chewers which resembled the ultrastructural features of experimental carcinogenesis and leukoplakia. It is concluded that chronic chewing of tobacco produces ultrastructural abnormalities in the esophageal mucosa which could be important precursors for esophageal malignancy.
Subject(s)
Basement Membrane/ultrastructure , Biopsy , Epithelium/ultrastructure , Esophagus/ultrastructure , Humans , Intercellular Junctions/ultrastructure , Microscopy, Electron , Mucous Membrane/ultrastructure , Plants, Toxic , Time Factors , Tobacco, Smokeless/adverse effectsABSTRACT
In acute viral hepatitis, gastric biopsy and augmented histamine test were performed in 63 patients. Gastric histology was abnormal in 12 of 63 (19%) patients; 3 with superficial and 9 with atrophic gastritis. Maximal acid output was less than 10 mEq/h in 35 of 63 (55.5%) patients. Acid load tests were performed in 23 patients measuring H+, K+, Na+ fluxes; the results showed increased loss of acid from lumen to mucosa in 16 of 23 (69.6%) patients, indicating damage to the gastric mucosal barrier.