ABSTRACT
El objetivo de este estudio, fue determinar la prevalencia de estomatitis subprotésica y sus factores asociados en pacientes portadores de prótesis removibles. Estos pacientes pertenecieron al Departamento de Prostodoncia del Consultorio Miraflores y a la Clínica Odontológica de la Universidad Mayor entre Septiembre 2009 y Diciembre 2010. El total de pacientes examinados fueron 75 portadores de prótesis removibles. Se tomaron dos muestras a cada paciente, una proveniente del paladar y otra de su prótesis, con su posterior estudio microbiológico. El 68% de los pacientes presentó alteraciones en la mucosa palatina compatibles con estomatitis subprotésica. En el 74,6% de los pacientes con estomatitis subprotésica se aisló al menos una especie de Candida, no existiendo diferencia significativa. La prótesis dental removible influye notablemente en la aparición de la estomatitis subprotésica. Al aumentar la gravedad de la enfermedad, aumenta la presencia de Candida, siendo Candida albicans la más prevalente en pacientes con estomatitis subprotésica.
In the present study, we determined the prevalence of denture stomatitis and its associated factors in patients that use removable denture. These patients come from the prosthetics clinic of the Miraflores Clinic and from the dental clinic of the Universidad Mayor between September 2009 and December 2010. The total of 75 patients with removable dentures were examined, two samples were taken of each patient, one of their palate and other of their prostheses, for performing microbiological studies. The 68% of the patients showed alterations in the palate mucosa subprotesic compatible with stomatitis. 74.6% of patients with denture stomatitis isolated at least one species of Candida, with no meaningful evidence. Removable dental prosthesis substantially affects the appearance of denture stomatitis. When the severity of illness increases the presence of Candida also increases, Candida albicans being the most prevalent in patients with denture stomatitis.
ABSTRACT
Pemphigus is an autoimmune bullous disease that involves skin and mucous membranes caused by autoantibodies against antigens on the surface of keratinocytes. We report a 30-year-old mole presenting with a five months history of pruriginous alopecic and crusted lesions in the scalp, that extended posteriorly to the trunk and limbs. Mucous membranes were not involved. A skin biopsy was performed, showing extensive loss of epidermis and acantholysis. Immuno fluorescence waspositivefor C3 and intercellular and epidermic IgG. With the presumptive diagnosis of pemphigus vulgaris (PV) without mucous involvement, thepatient was treated with prednisone, observing an excellent clinical response. There are only few cases published in the literature of PV without mucous involvement. Some authors refer to this subtype of PV as "Cutaneous pemphigus vulgaris".
Subject(s)
Adult , Humans , Male , Pemphigus/pathology , Biopsy , Glucocorticoids/therapeutic use , Pemphigus/drug therapy , Prednisone/therapeutic use , Scalp Dermatoses/drug therapy , Scalp Dermatoses/pathologyABSTRACT
Foram coletadas sessenta e oito amostras em diferentes solos paraibanos, com o isolamento de quarenta e nove cepas de Streptomyces spp. Após triagem antimicrobiana, por meio da técnica de difusão em meio sólido com blocos de agar, foram preparados os extratos dos microrganismos produtores de metabólitos bioativos, respectivamente cepas SP1 e SP3, e em seguida avaliados quanto a atividade antifúngica frente a espécies de fungos filamentosos de origem clínica e ATCC. O antagonismo foi determinado através dos ensaios de difusão com discos em meio sólido, microdiluição e cinética de morte microbiana. Os halos de inibição obtidos a partir dos extratos Sp-1 e Sp-3 apresentaram efeito antagônico com valores superiores aos halos de inibição promovidos pela droga controle, frequentemente utilizada na terapêutica antifúngica. Os resultados das concentrações inibitórias mínimas na microdiluição foram expressivos com valores fungicidas variando entre 10 mg e 0,078125 mg. Na cinética de morte microbiana, as atividades dos extratos Sp-1 e Sp-3 resultaram em dados estatisticamente significativos frente às cepas testes.
Sixty eight samples were collected in different soils of Paraiba, with the isolation of forty nine strains of Streptomyces spp. After screening antimicrobial followed the method of diffusion in solid medium with agar block, the extracts were prepared from microorganism producers of bioactive metabolites, respectively strains SP1 and SP3, and then evaluated for antifungal activity against strains of filamentous fungi of clinical origin and ATCC. The antagonism was determined through testing of diffusion disc in solid medium, microdilution and kinetics of microbial death. The inhibition zones obtained from extracts of Sp-1 and Sp-3 showed antagonistic effect with values greater than the halos of inhibition promoted by the drug control, often used in antifungal therapy. The results of minimum inhibitory concentrations in microdilution were significant with fungicide values ranging between 10 mg and 0.078125 mg. In the kinetics of microbial death, the activities of the extracts Sp-1 and Sp-3 resulted in statistically significant data front of strains tested.