ABSTRACT
Introducción: La aterectomía direccional es una técnica mínimamente invasiva que puede ser utilizada para evitar la amputación de los miembros inferiores en caso de isquemia crítica. Caso: Se presenta la primera experiencia en Ecuador, realizada en una paciente diabética e insuficiente renal. Este procedimiento logró repermeabilizar el segmento femoropoplíteo izquierdo con éxito. Discusión: La aterectomía direccional es una alternativa eficaz, mínimamente invasiva, para evitar la amputación de miembros inferiores en pacientes isquemia crítica y múltiples comorbilidades. Palabras clave: Aterectomía, isquemia, miembro inferior, pie diabético.
Introduction: Directional atherectomy is a minimally invasive technique that can be used to avoid lower limb amputation due to critical ischemia. Case report: This is the first experience in Ecuador, using this technique in a diabetic patient with chronic renal failure. The procedure achieved successful recanalization of the left femoropopliteal artery. Discusion: Directional atherectomy seems to be an alternative to avoid limb amputation in patients with critical ischemia and several comorbidities.
Subject(s)
Aged , Atherectomy , Diabetic Foot , Lower Extremity , Ischemia , Diabetes Mellitus , Peripheral Arterial Disease , Amputation, SurgicalABSTRACT
The Endosperm Balance Number (EBN) is an important concept for potato breeding and has evolutionary importance in tuber-bearing Solanum species. The EBN is part of the post-zygotic hybridization barriers in the group and represents a reproductive isolating mechanism. Few genes have been proposed to be involved in its genetic control; until now, however, neither specific genes nor its molecular basis have been well established. Histological observations of embryo and endosperm development in inter-EBN crosses in tuber-bearing Solanum revealed phenotypes similar to those recently described in Arabidopsis seed mutants. The common feature between them is that the endosperm nuclei become greatly enlarged and that embryos are arrested at the globular stage. The proteins encoded by the Arabidopsis TITAN genes are related to chromosome dynamics and cell division. Based on the sequence of titan mutants, genes in potato species related to cell cycle and microtubule assembly were isolated. In this article a perspective model is proposed to explore the utility of Arabidopsis mutants associated with cell cycle control as a tool to elucidate the molecular basis of EBN in potato. Further research focused on the expression pattern of these genes in intra- and inter-EBN crosses in potato species will be performed.
Subject(s)
Humans , Animals , Arabidopsis/embryology , Arabidopsis/genetics , Arabidopsis/metabolism , Crosses, Genetic , ADP-Ribosylation Factors/chemistry , Phenotype , Ploidies , Solanum/embryology , Solanum/genetics , Solanum/metabolism , Cell Cycle , Gene Expression Regulation, Plant , Molecular Sequence Data , Mutation , Plant Proteins/genetics , Plant Proteins/chemistry , Sequence AlignmentABSTRACT
Se realiza un análisis retrospectivo para evaluar el diagnostico, tratamiento y seguimiento en 39 pacientes con tumores testiculares tratados en Solca-Quito en un período comprendido entre 1987-1991. Concluyendose que la edad promedio fue de 31.2 años de los 24 casos remitidos a la Institución el 70 por ciento tuvieron una evaluación prequirugica inadecuada. Los métodos de diagnostico más usuales fueron: Palpación testicular, Ecografía testicular, Abdominal, TAC, y marcadores tumorales teniendo estos una alta sensibilidad y especificidad para la determinación de la extensión de la enfermedad. El 41.1 por ciento de pacientes abandonaron los controles. El 38.4 por ciento de pacientes mantienen controles en forma períodica. Existió una mortalidad del 15.3 por ciento de pacientes.