ABSTRACT
Cranial CT scans of eleven immunocompetent children with central nervous system (CNS) infection due to Cryptococcus neoformans var. gattii were retrospectively reviewed. These children had an average age of 8.8 years and positive culture for C. n. var. gattii in cerebrospinal fluid. The most common signs and symptoms were headache, fever, nuchal rigidity, nausea and vomiting. No normal cranial CT was detected in any patient. Hypodense nodules were observed in all patients . The remaining scan abnormalities were as follows: nine had diffuse atrophy, six had hydrocephalus, and five had hydrocephalus coexistent with diffuse atrophy
Subject(s)
Humans , Male , Female , Child , Brain Diseases , Cryptococcosis , Cryptococcus neoformans , Tomography, X-Ray Computed , Brain Diseases , Cerebrospinal Fluid , Cryptococcosis , Cryptococcus neoformans , Follow-Up Studies , Retrospective StudiesABSTRACT
Relatam-se 14 casos de criptococose em crianças, diagnosticados em Belém, PA. Em nove pacientes a variedade do agente etiológico foi estudada e identificada como Cryptococcus neoformans var. gattii. A média de idade destes pacientes foi 7,8 anos (variaçäo, 5-13 anos). Havia 5 meninas e 4 meninos (razäo, 1,25:1). Cinco foram a óbito em três meses apesar do tratamento com anfotericina B (associada com fluconazol 3 ou fluocitosina 1). Säo comentados a existência de áreas de alta endemia da infecçäo por var. gattii no Pará e a gravidade da doença causada por essa variedade fúngica