Subject(s)
Humans , Male , Adolescent , Lymphangioma/diagnosis , Lymphangioma/pathology , Skin Neoplasms/diagnosis , Skin Neoplasms/pathology , BiopsySubject(s)
Humans , Female , Adult , Erythema/diagnosis , Erythema/pathology , Diagnosis, DifferentialABSTRACT
Las metástasis cutáneas son infrecuentes, reportándose en la literatura rangos entre 0,6 por ciento y 10 por ciento. El cáncer de mama es la neoplasia más común en las mujeres con metástasis cutáneas. La presencia de éstas constituye un signo de enfermedad avanzada y es indicadora de mal pronóstico. Las lesiones pueden tener distintos patrones clínicos: tipo nodular, erisipeloide, alopecia y carcinoma telangiectásico. En el presente artículo se realiza un análisis retrospectivo de tres casos clínicos atendidos en nuestro centro y una revisión de la literatura.
Cutaneous metastases are unusual; their frequency in the literature ranges from 0.6 percent to 10 percent. Breast cancer is the most common cancer in women with cutaneous metastases. They are perceived as a sign of advanced disease and are regarded as a serious prognostic indicator. The lesions may present in distinct clinical forms: nodular pattern, erysipelas like presentations, alopecia and carcinoma telangiectaticum. In this article we analyzed three clinical cases that were seen in our center and a review of the literature.
Subject(s)
Humans , Female , Middle Aged , Adenocarcinoma/secondary , Skin Neoplasms/secondary , Skin Neoplasms/therapy , Breast Neoplasms/pathology , Breast Neoplasms/therapyABSTRACT
Newborn fat necrosis is an unfrequent disease that compromises the adipose tissue and develops during the first weeks of life. It is characterized by reddish-purple nodules and/or plaques with a hard elastic consistency, isolated or múltiple, localized at the back, shoulders, buttocks, arms, thighs and chin. They evolve spontaneously to regression and unfrequently develop complications, being hypercalcemia the most observed. The pathogenesis of newborn fat necrosis is unknown, although certain risk factors for its development have been identified. Case-report: A 36 weeks preterm male newborn with a clinical picture compatible with fat necrosis. The diagnosis was made according to the clinical findings and his perinatal history, confirming it with pathology. The patient evolution was complete improvement and regression of the lesions, without complications.
La necrosis grasa del recién nacido (NGRN) es una rara enfermedad que afecta al tejido adiposo y que se desarrolla durante las primeras semanas de vida. Se caracteriza por nodulos y/o placas eritemato-violáceas, de consistencia duro-elástica, únicas o múltiples, en dorso, hombros, glúteos, brazos, muslos y mejillas, que evolucionan espontáneamente hacia la regresión. Si bien pueden desarrollarse complicaciones, éstas son infrecuentes, siendo la más importante la hipercalcemia. La patogenia de la NGRN es desconocida, aunque se han identificado factores predisponentes para su desarrollo. Presentamos el caso de un recién nacido de pretérmino de 36 semanas, sexo masculino, que presentó un cuadro clínico compatible con NGRN. El diagnóstico se sospechó en base a la clínica, a los antecedentes perinatales y se confirmó con el estudio histopatológico. El paciente evolucionó satisfactoriamente con regresión de las lesiones y sin presentar complicaciones hasta la fecha.
Subject(s)
Humans , Male , Infant, Newborn , Hypercalcemia/etiology , Fat Necrosis/complications , Fat Necrosis/diagnosis , Biopsy , UltrasonographyABSTRACT
Presentamos el caso de una paciente de 62 años con un cuadro de tres años de evolución, caracterizado por placas y pápulas eritematosas arciformes que comenzaron en cara, extendiéndose luego al resto del cuerpo, asociado a baja de peso y depresión. Después de un completo estudio y dos biopsias de piel se diagnóstica eritema necrolítico migratorio (ENM). El ENM junto con estomatitis/glositis, baja de peso, diarrea, diabetes y anemia forman el síndrome paraneoplásico asociado al tumor de células a pancreáticas, llamado síndrome del glucagonoma, El ENM corresponde a lesiones maculopapulares, coalescentes, de borde serpiginoso, acompañadas de una bula central que se erosiona y forma costras. La biopsia cutánea muestra hiperplasia psoriasiforme y espongiótica, paraqueratosis y separación de las capas superficiales de la epidermis. La resección del tumor conduce a la resolución del ENM. Presentamos este caso y revisión del tema por la baja frecuencia de esta enfermedad y para reforzar lo importante de su sospecha temprana.
We report the case of o 62 year old woman with a 3 year history of erythematous arciform plaques and papules that began in the face and spread to the rest of the body. These lesions were associated with depression and weight loss. After a comprehensive study and two skin biopsies, necrolytic migratory erythema (NME) was diagnosed together with glossitis/stomatitis, weight loss, diarrhea, diabetes and anemia, NME is part of the paraneoplastic syndrome associated with a cell pancreatic tumor, known as glucagonoma syndrome NME lesions are characterized by a coalescent maculopapular rash with a serpiginous edge and a central bulla that erodes and become crusted. Histological studies show a psoriasiform and spongiotic hyperplasia, porakeratosis, and detachment of the superficial layers of the epidermis. ENM usually resolves after tumor resection. We present this case and a review of the literature because of the low frequency of this disease and to reinforce the importance of its early suspicion.
Subject(s)
Humans , Female , Middle Aged , Erythema/etiology , Glucagonoma/diagnosis , Pancreatic Neoplasms/diagnosis , Glucagonoma/surgery , Glucagonoma/complications , Pancreatic Neoplasms/surgery , Pancreatic Neoplasms/complications , Paraneoplastic Syndromes/etiology , Treatment OutcomeSubject(s)
Humans , Biomarkers, Tumor/metabolism , Melanoma/diagnosis , Melanoma/metabolism , Skin Neoplasms/diagnosis , Skin Neoplasms/metabolism , /metabolism , Antigens, Neoplasm/metabolism , Microphthalmia-Associated Transcription Factor/metabolism , Immunohistochemistry , Monophenol Monooxygenase/metabolism , /metabolismABSTRACT
We report a 33 year-old female presenting with a 2 cm tumor of the upper lip lasting one year. The tumor was excised and the pathological examination showed multiple blood vessels with thickened walls, prominent endothelial cells, lymphoid follicles and an increased number of eosinophils. The final diagnosis was an angiolymphoid hyperplasia with eosinophilia. Six months after surgery, the patient was free of disease. This is a rare condition that must be distinguished from Kimura disease.
Subject(s)
Adult , Female , Humans , Angiolymphoid Hyperplasia with Eosinophilia/pathology , Lip Diseases/pathology , Adenoma, Pleomorphic/diagnosis , Angiolymphoid Hyperplasia with Eosinophilia/surgery , Biopsy , Diagnosis, Differential , Lip Diseases/surgery , Salivary Gland Neoplasms/diagnosisSubject(s)
Humans , Female , Adult , Pyoderma Gangrenosum/diagnosis , Pyoderma Gangrenosum/pathologyABSTRACT
Se presenta un caso de una paciente de 33 años, con evidencias clínicas de cuadro de vasculitis con compromiso cutáneo y articular, que cursa con dolor abdominal en fosa ilíaca derecha y signos de irritación peritoneal. Se interviene encontrándose un apéndice cecal levemente inflamado. Evoluciona en buenas condiciones con remisión de la sintomatología articular y cutánea, luego de recibir un tratamiento con corticoides. El estudio de laboratorio comprueba la existencia de un lupus erimatoso sistémico (LES). La biopsia demostró una apendicitis por vasculitis con necrosis fibrinoide de los vasos medianos. Se recomienda la utilización de los índices de actividad lúpica para orientar la sospecha diagnóstica entre una apednicitis aguda habitual y una inflamación del órgano secundario a la enfermedad lúpica
Subject(s)
Humans , Adult , Female , Appendicitis , Lupus Vasculitis, Central Nervous System , Appendicitis , Lupus Vasculitis, Central Nervous SystemABSTRACT
Herpes gestationis es una rara enfermedad autoinmune que se presenta en mujeres embarazadas, compromete principalmente la piel y puede manifestarse como lesiones bulosas intensamente pruriginosas que, en ocasiones, son de difícil diagnóstico. Nosotros reportamos 2 casos clínicos simultáneos que se presentaron en nuestro servicio en marzo del año 2002, hecho que no deja de sorprender dado lo infrecuente y poco común de esta patología
Subject(s)
Humans , Adolescent , Adult , Female , Pregnancy , Pemphigoid Gestationis , Pregnancy Complications , Adrenal Cortex Hormones , Diagnosis, Differential , Eosinophils , Pemphigoid Gestationis , Pregnancy Complications , Pregnancy Trimester, Second , Pregnancy Trimester, ThirdABSTRACT
We report a 35 years old female with a profound rectosigmoidal endometriosis, who had been subjected to multiple laparoscopic procedures and open surgery due to infertility in the last five years. Main presenting symptoms were cyclic hematochezia during the menstrual periods associated to pelvic pain. Colonoscopy was inconclusive, barium enema showed a marked stenosis of the zone, appearing as an extrinsic compression. CAT scan showed a homogeneous, solid parauterine mass. During surgery, an inflammatory mass with multiple endometriotic foci was found. A low anterior resection with mechanical anastomosis was done, preserving the uterus and left adnexa. Two months later, the patient became pregnant and an elective cesarean section was done at 38 weeks of gestation, giving birth to a healthy newborn. Radical resective surgery for rectosigmoidal endometriosis is indicated in patients with intense and recurrent symptoms in whom hormonal treatment has failed and when a tumor cannot be discarded. The fertility rate, when adnexa and uterus are preserved, is 40 percent and symptomatic improvement is achieved in 85 percent of patients