ABSTRACT
Background: Esophageal candidiasis is associated with conditions that cause an immune depression. It is a defining disease for AIDS, is observed in poorly controlled diabetics, in patients with renal or hepatic failure, in patients with cancer and in subjects using medications causing immunosuppression or broad spectrum antimicrobials. Aim: To report the features of 10 immunocompetent patients with esophageal candidiasis. Patients and methods: Six males and four females aged between 48 and 82 years, without conditions associated with immunosuppression, in whom an esophageal candidiasis was found on an upper gastrointestinal endoscopy. Delayed skin hypersensitivity to eight antigens, Iymphocyte subpopulations, yeast phagocytosis and neutrophil chemotaxis were measured. Results: Six patients had a low CD4 Iymphocyte count and seven had a low CD8 count. Seven patients were anergic on skin hypersensitivity challenge. Yeast phagocytosis was abnormal in one patient and neutrophil chemotaxis was abnormal in two. Humoral immunity was normal in all subjects. All patients were treated with oral fluconazole in doses of 150 mg/day for 14 days, with complete resolution of candidiasis in all. Conclusions: Patients with esophageal candidiasis, have frequent alterations of cellular immunity, that must be diagnosed and treated.
Subject(s)
Humans , Male , Female , Middle Aged , Candidiasis/immunology , Esophageal Diseases/microbiology , Immunocompetence/immunology , /immunology , Candidiasis/complications , Esophageal Diseases/immunology , Gastroscopy , Hypersensitivity, Delayed , Prospective StudiesABSTRACT
The most successful therapy for acute liver failure is liver transplantation. However, due to the low number of donors, organ support therapies need to be used as a bridge to liver transplantation. Molecular Adsorbents Recirculating System (MARS) is a dialysis treatment that uses a recirculating dialysate containing albumin. This allows the removal of both hydrosoluble and albumin-related substances. This system improves hepatic encephalopathy, renal dysfunction and some clinical parameters in acute liver failure, but there is no clear decrease in mortality. We report three women aged 23, 21 and 61 years, that were subjected to liver transplantation, in whom this therapy was successfully used.
Subject(s)
Humans , Adult , Female , Middle Aged , Liver, Artificial , Liver Transplantation , Liver Failure, Acute , Hepatic Insufficiency/therapyABSTRACT
A 32 years old female was admitted to hospital due to acute abdominal pain, nausea, vomiting and liquid stools. Physical examination was normal except for pain on her left inferior abdominal quadrant without peritoneal irritation signs. An abdominal CAT-scan suggested thrombosis at celiac trunk, although the echo Doppler showed no alterations except for signs of ischemia in the distal branch of the superior mesenteric artery. An exploratory laparotomy was performed disclosing a necrosis of the distal ileum and cecum, diffuse peritonitis and thrombosis of the ileocecoapendiculocolic artery. No vasculitis lesions were found in the arteries of medium size examined. A history of intermittent claudication for the past 3 years as well as acrocyanosis, asymmetry of pulses and blood pressure in the superior extremities was ascertained after the surgery. A MRI angiogram showed multiple stenoses and irregularities at the celiac trunk, hepatic, superior mesenteric and fibular arteries. No abnormalities at the aortic arch and its main branches were documented. A sepsis due to Candida sp complicated her postoperatory period. After recovery, prednisone 1 mg/kg/day was started and the anticoagulation continued. The abdominal pain, intermittent claudication and superior limb acrocyanosis disappeared. This is an unusual case of type IV Takayasu's arteritis with acute abdominal signs as the first manifestation
Subject(s)
Humans , Adult , Female , Takayasu Arteritis , Intestines , Necrosis , Adrenal Cortex Hormones , Thrombophilia , Ischemia , Intermittent Claudication/etiologyABSTRACT
Legionella pneumophila is the second cause of severe community acquired pneumonia. In Chile, however, there are few reports of pneumonia caused by Legionella. We report eight patients (6 men, aged 42 to 72 years old) with community-acquired pneumonia caused by Legionella pneumophila serogroup 1, confirmed by the measurement of urinary antigen. Clinical presentation was characterized by fever or hypothermia (in one case), cough, dyspnea and neurological abnormalities in four patients. Cigarette smoking was the most frequently identified risk factor. All patients had at least one American Thoracic Society severity criteria. Complications observed were acute hypoxemic respiratory failure in seven patients, shock in four, renal failure in four and need for mechanical ventilation in three. No patient died
Subject(s)
Humans , Male , Adult , Female , Middle Aged , Legionnaires' Disease , Legionella pneumophila , Pneumonia, Bacterial/etiology , Legionnaires' Disease , Legionella pneumophila , Antigens, Bacterial/urine , Antigens, BacterialABSTRACT
Se estudiaron retrospectivamente 10 casos de Hígado Graso Agudo del Embarazo (HGAE) entre los años 1990 y 2001. Se describen los hallazgos clínicos y de laboratorio de la enfermedad, analizando su asociación con el síndrome hipertensivo del embarazo (SHE) y estableciendo el rol diagnóstico de la biopsia hépatica percutánea de esta patología. Se propone que el desenlace en falla hepática aguda podría gatillarse por eventos precipitantes compartidos por un mismo espectro de enfermedades (HGAE y SHE). Se concluye que el estudio anatomopatológico hépatico es discutido como pilar diagnóstico y se ofrece una aproximación actual al enfrentamiento de esta entidad