ABSTRACT
Objective:To detect the levels of PA,FN,RBP,CRP,Iron,Zinc,VitD in peripheral blood of children with HFMD and to explore the relationship between them and the disease .Methods:The levels of PA,FN,RBP and CRP were detected by immune turbidimetric assay;and the levels of Iron and Zinc were detected by flame atomic absorption spectrometry ;while the levels of VitD were detected by electro chemilumin escence .Results:The levels of PA,FN,RBP,Iron,Zinc and VitD in the severe group were lower than those in other groups ,while the levels of CRP were higher than those in other groups ( P0.05 ) .The levels of PA,FN,RBP,Fe,Zn and VitD in the convalescence were higher than those in the acute phase of the severe cases (P0.05).There were negative correlation between the levels of PA ,FN,RBP and the state of HFMD(P<0.05),while there were positive correlation between the levels of CRP and the state of HFMD (P<0.05). And there were low negative correlation between the levels of Iron , Zinc, VitD and the state of HFMD ( P <0.05 ), respectively.Conclusion:There were nutritional deficiency in severe cases of HFMD ,and the nutritional status should be assessed dy-namically,then proper amount of nutrition should be supplement .
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Objective:To determine the level of FIB,IL-6,D-dimer and explore the differential diagnostic value and clinical significance of the tumor markers in patients with ovarian cancers.Methods: The level in serum of 65 ovarian cancer and 35 benign tumor of ovarian and 30 controls FIB and D-dimer were measured by latex agglutination assay.The IL-6 levels were measured by ELISA method.Results:Compared with the normal controls and benign tumor of ovarian cancer, there were some significantly changes in ovarian cancer patients including FIB,IL-6,D-dimer increased (P0.05).Companied with TNM stage increased,the levels of FIB,IL-6,D-dimer ovarian cancer groups increased.The correlation analysis showed that FIB was positively correlated with D-dimer and IL-6 (r=0.56,r=0.31).Conclusion:The level of serum FIB,D-dimer,IL-6 detection in patients with ovarian cancer are helpful in early diagnosis, dicision of clinical stages and regimen prognosis.
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Objective:To evaluate the alternation of homocysteine (Hcy),folic acid(FA),CA15-3 and vitaminB12(VitB12) in patients with breast cancer and explore the correlation of them.Methods:The levels of FA ,CA15-3 and VitB12 in serum of 55 breast cancer and 35 benign tumor of breast and 50 controls were measured by electro-chemiluminescence immunoassay ( ECLI ) , the Hcy levels were measured by colorimetric method.Results:Compared with the normal controls and benign tumor of breast cancer ,there were some significantly changes in breast cancer patients including Hcy ,CA15-3 increased and FA ,VitB12 reduced ( P＜0.05 ) ,there were no significant differences in Hcy,FA,CA15-3,VitB12 levels between benign breast tumors and normal controls (P>0.05).Companied with TNM stage increased ,the levels of FA breast cancer groups decreased ,the levels of Hcy,CA15-3 increased.The correlation analysis showed that Hcy was negatively correlated with FA and VitB 12,(r=-0.341,r=-0.540),CA15-3 was negatively correlated with FA, CA15-3 was postively correlated with Hcy (r=0.378,r=-0.361).Conclusion: Serum Hcy,CA15-3,FA and VitB12 detection in patients with breast cancer are helpful in the severity judgment and regimen prognosis .
ABSTRACT
Objective To investigate the characteristics of amino acids metabolism in breast cancer patients so as to provide theoretic evidence for nutrition support.Method The levels of free amino acids in plasma and urine were examined in 55 breast cancer patients and 50 normal controls with Hitachi L-8900 amino acid analyzer.Results Compared with the normal controls,the plasma level of methionine increased significantly in breast cancer patients [(48.22 ± 12.90) μmol/L,P =0.04),while the levels of 7 amino acids decreased,ineluding isoleucine [(43.07 ± 14.88) μmol/L,P =0.04],leucine [(93.22 ± 18.29) μmol/L,P =0.01],valine [(200.86 ± 42.11) μmol/L,P =0.04],arginine [(46.49 ± 11.79) μmol/L,P =0.00],lysine [(107.37 ±32.61) μmol/L,P=0.01],tyrosine [(29.51 ±18.09) μmol/L,P=0.02] and phenylalanine [(57.39 ± 17.03) μmol/L,P =0.00],and branched chain amino acids/aromatic amino acid decreased to 1.81 ± 0.81 (P =0.04).Compared with the normal controls,the urine levels of phenylalanine [(22.01 ± 4.37) μmol/L,P=0.01],tyrosine [(12.13 ±5.72) μmol/L,P=0.02] and lysine [(107.37 ± 32.61) μmol/L,P =0.00] increased significantly in breast cancer patients,while the urine levels of leucine [(0.84 ±0.21) μmol/L,P =0.04] and valine [(0.50 ± 1.10) μmol/L,P =0.01] decreased significantly,and the ratio of branched chain amino acids/aromatic amino acid dropped to 1.91 ± 0.60 (P =0.03).Conclusions There is metabolic disorders of amino acids in patients who breast cancer.The focus of the amino acid imbalance treatment for breast cancer patients are supplementation of branch amino acids and arginine.