ABSTRACT
Objective:To investigate the prognostic value of albumin to globulin ratio (AGR) combined with prognostic nutrition index (PNI) in patients with resectable gastric cancer (rGC).Methods:From January 2015 to December 2017, 158 patients with rGC who underwent radical gastrectomy in Rugao Hospital were included, and followed up until May 2020 or died. The preoperative AGR and PNI were calculated. The cut-off value of AGR and PNI were determined by receiver operating characteristic (ROC) curve. The relationship between AGR-PNI and clinicopathological indicators were analyzed. The Kaplan-Meier method was used to calculate the cumulative overall survival rate. Log-rank test and univariate prognostic analysis were used. The Cox proportional hazards regression model was used for multivariate prognostic analysis.Results:The cut-off value of ROC curve of AGR and PNI were 1.19 and 43.70 respectively. The area under ROC curve (AUC) of AGR-PNI was larger than that of AGR and PNI ( Z = 2.596, P = 0.009; Z = 2.403, P = 0.016). Patients were divided into three groups: group 0 (AGR ≥ 1.19, PNI ≥ 43.70; 75 cases), group 1 (AGR ≥ 1.19, PNI < 43.70, or AGR < 1.19, PNI ≥ 43.70; 55 cases), group 2 (AGR <1.19, PNI < 43.70; 28 cases). The age, sex, tumor diameter, TNM stage and degree of tissue differentiation were significantly different among three groups ( P < 0.05). The results of multivariate analysis showed that age (≥ 60 years old vs. < 60 years old, HR = 1.878, 95% CI1.011-3.491, P = 0.046), TNM stage (Ⅲ stage vs. Ⅰ stage, HR = 2.148, 95% CI 1.074-4.296, P = 0.031), degree of tissue differentiation (moderate or good vs. poor, HR = 0.399, 95% CI 0.211-0.753, P = 0.005), AGR-PNI (group 2 vs. group 0, HR = 2.729, 95% CI 1.303-5.715, P = 0.008) were independent risk factors for survival of patients with rGC. Conclusions:AGR-PNI can be used as an effective predictor of the prognosis of rGC patients, and high grouping indicates poor prognosis.
ABSTRACT
Objective To preliminaryly explore the effect and adverse reaction of Marine Injection combined therapy through local spray in benign tracheobronchial stenosis.Methods 19 cases of bronchial tuberculosis were collected in our department.By assessing cough,shortness of breath and other symptoms,chest high -resolution CT (HRCT)of three -dimensional reconstruction,and length were observed by ultrafine bronchial stenosis.According to the pathogeny and types of stenosis,combined multiple intervention were sequentially adopted,and then Marine Injec-tion was sprayed through one -off endoscopic spray tube.All the subjects were divided into the two groups,the higher concentration Marine injection (1 200 mg/mL)group was chosen with the condition of serious inflammation,edema, ulcer and necrosis,obvious local granulation tissue hyperplasia,severe scar stenosis,and the length of stenosis greater than 2 cm or the sectional area of stenosis less than 50% of the normal sectional area,otherwise the low concentration (600 mg/mL)group was chosen.The subjects were reexamined by clinical symptoms,high -resolution CT (HRCT) of three -dimensional reconstruction,and ultrafine bronchoscopy a week after the surgery to dynamically observe the local changes.Depending on the situation,the injection was sprayed once a week,adding up to 2 -4 times.Follow -up visit lasted for 3 months,cough,expectoration or hemoptysis,and dyspnea were observed.Results 11 cases were effective fully,17 cases were effective substantially,7 cases were ineffective,the total effective rate was 80% (28 /35).The overall complication rate was 42.8% (15 /35),no deaths occurred.No complications related to local spra-ying of Marine were seen.Conclusion Local spray of Marine Injection may have preferable effect that inhibits scar formationand prevention airway restenosis.It is worth further study with a high security,precise clinic effect,easy oper-ation and etc.
ABSTRACT
Objective To retrospectively analyze of clinical application of BF-XP60 micro-bronchoscopy.Methods 135 clinical data of patients who adopted ultrafine micro-bronchoscopy and intervention were collected and analyzed for the complications.Results The frequency of local rhinomusoca damaging and errhysis was in 3 cases,the mucous of the glottis damaging and errhysis was in 2 cases,local mucous of the tracheal bronchus errhysis was in 3 cases.After intervention,the frequency of fever was in 13 cases,massive haemorrhage was in 1 case,pneumothorax was in 1 case,chest pain was in 2 cases,part fiber of inner untrafine micro-bronchoscopy broken was in 2 cases,check failure due to ultrafine micro-bronchoscopy broken in trachea was in 4 cases,and arrhythmia,asphyxia,and death were in 0 case.The overall incidence of side effects was 22.9％ (31/135).Conclusion Application of ultrafine micro-bronchoscopy was contributed to find the lesions within the bronchioles and around the lungs,moreover,it could evaluate the distal bronchus of airway obstruction which was planned to adopt intervention.The topic that how to reduce the incidence of the side effects of the micro-brohchoscopy and improve the success rate and safety of inspection and intervention was worth to be concerned.