ABSTRACT
Objective: To observe the clinical efficacy and adverse reactions of apatinib in advanced gastric cancer after routine chemotherapy. Methods: Thirty-one patients with unrespectable stage IV gastric cancer and had a deterioration or recurrence after at least 2 cycles of chemotherapy with thymidine phosphorylase-based regimen, were recruited in this study. The patients were given with 500-250mg of apatinib once daily till disease progression. A chest and abdomen CT or MRI scan was taken every 2 cycles for a response assessment. Results: Among the 31 patients, no one achieved complete response, 7 patients (22.6%) had partial response, 17 patients (32.3%) had stable disease; the disease control rates was 54.8%. The median time to progression was 4.0 months [95% confidence interval (CI): 3.2-4.8]. The median survival time was 5.3 months (95% CI: 3.2-7.4). The main adverse reactions were hypertension, hand foot syndrome, diarrhea, fatigue, proteinuria and liver function damage. Conclusion: Apatinib can obtain good clinical effect in treatment of advanced gastric cancer after chemotherapy resistant.
ABSTRACT
Objective To investigate the clinical significance of liver function and myocardial enzyme indexes in critically ill children, by the determination of liver function and myocardial enzymes in critically ill children. Methods Select children,with the application of pediatric critical illness scoring system to rate and decided 80 cases of critically ill children as a critical group,of which 18 cases were very critically ill children. And chose 80 cases of non-critically ill children as a control group. Determine liver function and myocardial enzymes of the cases given the appropriate treatment within the first hour of being hospitalized. Results The most critical group in children with the changes of liver function and myocardial enzyme in children above the critical group, while the critical group above the non-critical group, the greater the change, statistically significant (all P ＜ 0.05). Conclusion The liver function and myocardial enzymes not only could be used as indicators of the liver and myocardial injury,but also auxiliary diagnostic index in critically ill children,and had important clinical significance in judging the severity and prognosis of the disease.