ABSTRACT
OBJECTIVE:To investigate clinical efficacy of cerebroventricular perfusion and intrathecal perfusion of vancomy-cin assisting with continuous drainage in the treatment of intracranial infection secondary to traumatic brain injury,and its effects on cerebrospinal fluid indexes and intracranial pressure. METHODS:One hundred and eighty patients with intracranial infection secondary to traumatic brain injury selected from Sanya Hospital of TCM during Jan. 2012 to Jun. 2015 were randomly divided into control group and observation group according to lottery,with 90 cases in each group. They were given cerebroventricular perfu-sion and intrathecal perfusion of vancomycin(20 mg dissolved in 5 mL normal saline)in cella lateralis and lumbar cisterna respec-tively combined with continuous drainage,q12 h. Both groups received treatment for 7 d.Clinical efficacy,the time of infection con-trol were compared between 2 groups as well as body temperature,intracranial pressure and cerebrospinal fluid indexes before and after treatment,and the occurrence of ADR. RESULTS:After treatment,total response rate of observation group (95.56%) was significantly higher than that of control group (77.78%),with statistical significance (P0.05). CONCLUSIONS:The intrathecal perfusion of vancomycin as-sisting with continuous drainage in the treatment of intracranial infection secondary to traumatic brain injury can effectively speed up the rehabilitation process,reduce the body temperature and intracranial pressure,and is helpful to improve the relevant cerebro-spinal fluid indexes. Therapeutic efficacy of it is better than that of cerebroventricular perfusion.
ABSTRACT
Objective To observe the effect of Jianpi Tiaozhong Xiaopi Recipe ( JTXP) for the treatment of functional dyspepsia ( FD) with spleen deficiency and Qi stagnation. Methods A total of qualified 110 cases were evenly randomized into Chinese medicine group and western medicine group. Chinese medicine group was given modified JTXP orally, and western medicine group was given Mosapride and Lansoprazole orally. After treatment for one continuous month, therapeutic effect was evaluated and the improvement of clinical symptoms before and after treatment was observed. After follow-up for half a year, the recurrence of FD was observed. Results ( 1) After treatment for one month, the scores of abdominal distension and fullness, gastric vague pain, poor ap petite, belching and hiccup were obviously decreased in both groups compared with those before treatment ( P<0.05) , and the relief of the symptoms in Chinese medicine group was superior to that in western medicine group (P<0.05). (2) The total effective rate was 94.5% in Chinese medicine group and was 81.8% in western medicine group, the difference being significant ( P<0.05). ( 3) The results of follow up showed that recurrence of FD was shown in 3 cases (5.8%) of Chinese medicine group and in 8 cases (17.8%) of western medicine group, the difference being significant ( P<0.05). ( 4) During the treatment, no obvious adverse reaction was shown in both groups. Conclusion JTXP exerts certain therapeutic effect for the treatment of FD with spleen deficiency and Qi stagnation.