ABSTRACT
Objective: To investigate the effect of retrograde intra-renal surgery [RIRS] on kidneys using the myoinositol oxygenase [MIOX] enzyme. MIOX is a renal tubular-specific novel marker for the early diagnosis of acute kidney injury
Methods: A total of twenty seven individuals that had undergone RIRS to treat kidney stones were included in the study. Biochemical tests were performed on serum samples collected immediately before RIRS [hour 0] and at the 6th and 24th hours after the surgery
Results: The creatinine value at hour 6 was lower than the baseline [hour 0] value [p = 0.0305]. Cystatin C at hour 6 was lower than the value measured at hour 24 [p = 0.0142]. Similarly, MIOX was lower at hour 6 compared to hour 24 [p = 0.0214]. MIOX/creatinine at hour 6 was lower than the value calculated at hour 24 [p = 0.0348]. The basal values of MIOX and creatinine were found to have a positive correlation [correlation coefficient r = 0.5946, p = 0.0035]
Conclusions: Similar to the serum creatinine, the serum MIOX level provides information about kidney functions. RIRS was confirmed to be a safe procedure for the treatment of acute kidney injury with no negative effects on the kidneys