ABSTRACT
From the ethanolic extract of the leaves and thin branches of Duguetia trunciflora Maas (Annonaceae) six alkaloids were isolated, being one benzylisoquinoline: reticuline¹, four tetrahydroprotoberberine:,tetrahydro-palmatine², tetrahydrojathrorrizine³, discretamine4, thaicanine5, and one berberine: jathrorrizine6. These alkaloids were identified through ¹H and 13C NMR spectroscopic technics. The alkaloids 1, 3, 5 and 6 are being cited for the first time on Duguetia genus.
ABSTRACT
The genus Hornschuchia obliqua belonging to the Annonaceae family. The family comprising ca 130 genera and 2300 species, located in the Magnoliales, a primitive order of plants, is known to produce isoquinoline alkaloids derivatives1. Indeed the great majority of alkaloidal constituents of these plants are isoquinoline-derived structures, along with a wide range of non-alkaloidal compounds of varied stuctural types2,3. The present paper describes the chemical investigation of the alkaloids from Hornschuchia obliqua, isolated until now.
ABSTRACT
Uma investigação fitoquímica das vagens de Prosopis juliflora cultivada na região semi-árida do Estado da Paraíba e monitorada através de testes farmacológicos levou ao isolamento, purificação e identificação do alcalóide principal juliprosopina. A presença de outros constituintes químicos em mistura, tais como juliprosina e juliprosineno, foi verificada na fração dos alcalóides totais através de uma análise do espectro de RMN de 13C. Este trabalho sugere que a toxicidade, observada em animais de laboratório, está quimicamente relacionada com os alcalóides piperidínicos presentes nas vagens desta leguminosa.
A phytochemical investigation of the pods of Prosopis juliflora cultivated in the semi arid region of the State of Paraiba, monitored by pharmacological tests, led to the isolation, purification and identification of its main alkaloid - juliprosopine. The presence of other compounds such as juliprosine and juliprosinene, was observed through analysis of 13C NMR. This work suggests that the toxic activity, observed in laboratory animals, is chemicaly related with the piperidine alkaloids present in the pods of this Leguminosae.