ABSTRACT
It has been proposed that Thyroid Stimulating Hormone [TSH] influences leptin secretion from adipocytes. We evaluated the association between TSH and leptin levels in thalassemic patients with growth retardation. Blood samples were collected from 30 major thalassemic patients and 24 normal subjects [range: 12 - 20 y]. Both Leptin and TSH were measured by Enzyme-Linked Immunosorbent Assay [ELISA] method. The anthropometric data were collected based on standard methods. Independent sample t-test and Pearson's correlation were used to analyze data. Patients had severe growth retardation. Mean concentration of leptin in thalassemic patients was significantly lower than normal subjects [2.26 +/- 2.61 vs 13.14 +/- 15.95 ng/ml]. The mean value of serum TSH concentration in beta - thalassemic patients was higher than normal subjects. But the difference was not statistically significant [P = 0.146]. There was no marked relationships between TSH and leptin concentrations in thalassemic patients [r= -0.022, P = 0.909] and in control group [r=0.289, P=0.214]. In both beta - thalassemic patients and normal group leptin secretion is not affected by TSH concentration
ABSTRACT
Serum HDL cholesterol concentration may be affected by different factors. One of this factors is the race of each person. Therefore we studied HDL - cholesterol reference range in different ethnic groups in Ahwaz by regard to age and gender. Serum samples were drown from 601 males and 617 females randomly. This population was divided into main groups according their ethic [i.e Lor, Arab and Persian]. Each group was subdivided on the basis of age to three Subgroups [1-15,16-54and >54 years]. Serum HDL - cholesterol was determined with colorimetric method. All data were analyzed using the Statistical Package for the Social Sciences [SPSS] software [version 17.0]. Mean HDL - cholesterol Concentration in age subgroups of females was statistically different. [P<0.0001].While in males it was not apparent relationship between mean concentration Of HDL - Cholesterol concentration in age subgroups [P=0.630]. In male subgroups, mean HDL-cholesterol was significantly different [P<0.05]. Lor individuals had the highest and Arab individuals had the lowest mean HDL-cholesterol concentration. But in females such relationship was not seen. [P=0.743]. In male group the reference range of HDL cholesterol is affected by race and in female group the reference range of HDL-cholesterol is affected by age
ABSTRACT
Glucose-6-phosphate dehydrogenase [G-6-PD] is an enzyme which supports the cell membrane against oxidant agents. Acute deficiency of enzyme activity in G-6-PD deficient individuals, due to sensitivity of red blood cells membrane to the oxidative agents, leads to haemolytic anemia. There are some reports showing that diabetic patients are at the risk of G-6-PD deficiency. Thus the object of this clinical study was to investigate the percent of hyperglycemia in individuals who are G-6-PD deficient. One hudred and forty three patients [men and women in all ages] with G-6-PD deficiency were studied. In order to confirm the G-6-PD deficiency, Butler test was used, and then Fasting Blood Sugar [FBS] was determined by enzymatic method. Analytical studies were done by means of descriptive tables and, Pearson correlation tests. The mean concentration of FBS was 99.35 mg/dl which is within the normal range [70-100mg/dl]. In 86 G-6-PD deficient individuals [60.2%] FBS was within the normal range and in 57 [39.8%] G-6-PD deficient individuals FBS was higher than normal range. [normal range 70-100 mg/dl]. The mean FBS in men was not significantly different from women [P=0.7]. There is no significant correlation between FBS and age in both sexes. The results of this study suggest a relation between G-6-PD deficiency and diabetes mellitus; however more researches are required to clarify all aspects of this correlation