ABSTRACT
Background: Obesity is associated with increased rate of mortality and morbidity if untreated. Obesity is a health hazard it required attention towards adolescent and adult age group. Generally, body fat is distributed into two main compartments that are subcutaneous adipose tissue and visceral adipose tissue. Waist Hip Ratio measures the subcutaneous adipose tissue, determination of visceral adiposity will further helpful for determination of cardiovascular disease.Methods: The study comprised of 120 subjects, of these adolescents comprised of 60 healthy adolescent childrens. The adults comprised of 60 healthy individuals. In all the subjects, Height was estimated in centimetres and Weight was measured in kilogram measured and BMI was calculated. The waist hip ratio and visceral adiposity index was calculated. In all the subjects, venous blood was collected from all the subjects for lipid profile estimation.Results: In present study BMI more than 25 have soon increased waist hip ratio and visceral adiposity index value than BMI less than 25 and it’s statically significant in both adolescent and adult group. It is also reported that BMI more than 25 have increased level of mean serum triglycerides, serum total cholesterol, LDL cholesterol and VLDL the increase was statistically significant. The mean serum HDL cholesterol was significantly decreased in BMI>25 group when compared with BMI<25.Conclusions: It was concluded that different age groups of adolescent and adult, appropriate methods should be planned specifically for adolescent and adult age group. Regular educational sessions are needed to make changes adolescent and adults toward obesity.
ABSTRACT
Background: Based on Glomerular Filtration Rate (GFR) Chronic Kidney Disease patients are classified into five stages. It starts with early stage of CKD and finally ends with End Stage Kidney Disease (ESKD). Anemia and inflammation are major medical complication in End Stage Kidney Disease and leads cardio vascular complications like LVH.Methods: A cross sectional study carried out over a 2 year period in Department Nephrology and General Medicine OPD, MIMS, Vizianagaram, Andhra Pradesh, India 120 in which 60 are normal healthy individuals and 60 are End stage kidney Disease. In all the participants Serum creatinine, blood urea, Serum Iron, TIBC, TSAT% Serum ferritin, Serum CRP, IL-6 and TNF-α was measured. All the EDTA blood samples were analyzed for complete blood count. Results: The diagnostic criteria for CKD like blood urea and serum creatinine were significantly higher in ESKD. There is a significantly increased level of Left ventricular mass index in ESKD when compared with Control. The mean erythrocyte indices are decreased in ESKD. The mean serum iron, TIBC and TSAT% decreased ESKD. Whereas serum ferritin significant increase in ESKD group and the mean serum CRP IL-6 and TNF-α significant increase in ESKD group when compared with controlConclusion: Present study finding suggested that there is a raised inflammatory marker in ESKD patients due to inflammation and it further changes serum ferritin, serum iron and TIBC. The above altered factors leads to changes in erythrocyte indices and leads to anemia which ends with cardiovascular complication like Left Ventricular Hypertrophy.