Fixed drug eruption clinical and histopathological study

Sixty cases [50 males and 10 females] affected with fixed drug eruption attending the out patient clinic of dermatology and venereology department of the faculty of Medicine, Alexandria University were examined.Their ages ranged from 21 years to 58 years. Sulphonomides were found to be the commonest drug causing fixed drug eruption [33.33%]. Antibiotics including Tetracycline and ampicillin were next in frequency [23.33%]. Different histopathological changes were encountered. Hydropic degeneration resulting in pigmentary incontinence was the commonest finding [83.33%]. Other findings were in the form of epidermal cell necrosis, oedema of epidermis and upper dermis, dermal cellular infiltration and picture stimulating vasculitis