ABSTRACT
Introduction: Sickle disease is one of the oldest geneticdisorders of medical science. Sickle cell disease affectsmillions of people worldwide. The morbidity and mortalityassociated with the disease, complications and sicklecell crisis is a significant health issue. Hydroxyurea is ananticancer agent, which proved to be the wonder drug in lowerdoses in sickle cell disease. Objective: To evaluate the serumelectrolytes level in sickle disease patients and find out theeffect of hydroxyurea.Material and methods: Thirty sickle cell disease patientsand twenty normal individuals as controls are included in thestudy. 11 patients on hydroxyurea therapy and 19 are nonhydroxyurea therapy. The serum levels of sodium, potassium,chloride, calcium, magnesium and phosphate were estimatedin all the study subjects.Results: There is significant difference observed among TotalBilirubin, Urea, and Creatinine and chloride levels amongSickle disease patients compared with normal individuals.No much significant results were observed among patients onhydroxyurea therapy and non- hydroxy urea therapy exceptfor Total bilirubin and Sodium levels.Conclusion: Electrolytes plays crucial role in the pathphysiology of sickle cell disease, but hydroxyurea therapydoes not seem to alter the electrolyte levels in patients.