ABSTRACT
Designing and formulating an ideal pharmaceutical product is a very tedious job for a formulator as it comprises of multiple objectives. The traditional method followed for years is not only expensive and time consuming but it also needs lot of effort to be put in and in spite of that at times it proves to be unfavourable and unpredictable too.The recent approach to optimise i.e. to achieve the best combination of product and process characteristics under the given conditions is by using Design of Experiment (DoE).Design of Experiment (DoE) is an organised approach to determine the relationship between the factors (Xs) affecting a process and the output of that process (Ys).The recent optimisation methodologies include various approaches that come under the 2 main categories namely, simultaneous optimisation and sequential optimisation. Nowadays there are various software available to carry out the optimisation of pharmaceutical products.
ABSTRACT
An oral route of drug administration is the most popular route of administration. It have wide acceptance up to 50-60% of total dosage forms. Tablet is the most popular dosage forms existing today because of its convenience of self administration, compactness and easy manufacturing; however hand tremors, dysphasia in case of geriatric patients, the underdeveloped muscular and nervous systems in young individuals and case of uncooperative patients, the problem of swallowing is common phenomenon which leads to poor patient compliance. Mouth dissolving tablets (FDT) or fast dissolving tablets; (FDT) has emerged as alternative oral dosage forms. These are novel types of tablets that disintegrate/dissolve/disperse in saliva within few seconds. Fast dissolving tablets (FDTs) have received ever-increasing demand during the last decade, and the field has become a rapidly growing area in the pharmaceutical industry. This article reviews the Need, advantages, challenges, limitations, mechanism of superdisintegrants, various formulation technologies (conventional and patented), marketed product of Fast dissolving tablets.
ABSTRACT
The colon is the terminal part of the GIT which has gained as a potential site for delivery of various novel therapeutic drugs i.e. peptides. Colon targeted drug delivery system (CDDS) is an Promising tool for treatment of inflammatory bowel diseases such as ulcerative colitis, crohn’s disease, colon cancer, amobebiasis by both systemic and topical delivery of dug. This article review a detailed study about disease of colon, diagnosis of diseases of colon, anatomy of colon, factors affecting drug absorption and different approaches of colon including some current approaches like Pulsinicap system, Port system, Probiotic approach, Chronotropic system, Colal-pred system, Enterion capsule Technology Muliparticulate system and some past studies on colon drug delivery with evaluation method for site specific drug delivery to colon.