ABSTRACT
Objective To compare the hemostatic efficacies and exothermic reactions between mesoporous and microporous materialswith similar components but different specific surface areas and pore sizes, so as to lay a foundation for developing new first-aid hemostat with mesoporous materials. Methods Totally 15 male pigs were made into femoral artery fatal hemorrhage models and were randomly divided into three average groups (group A, group B and group C). Their hemostatic efficacies and exothermic reactions on the tissues were compared between the three groups (group A was treated with hemostatic mesoporous material HW, group B with microporous material ZSM-5, and group C with standard gauze as control). Results The hemostatic time periods of group Aand B were (49. 50±3. 27) s and (59. 50±2. 42) s, respectively (P<0. 05); standard gauze in group C had failed hemostatic effect. The highest local temperature rose to (42. 0± 1. 58) °C in group A, (46. 4±1. 14)°C ingroup B, and (36. 8±0. 84)°C in group C, with significant difference found between different groups (P<0. 05). Histological test showed that the tissue damage caused by exothermic reaction of mesoporous material HW was slighter than that of microporous material ZSM-5. Conclusion Compared to mesoporous material HW, the microporous material ZSM-5 has more rapid hemostatic efficacies and slighter exothermic reaction, and ZSM-5 is a promising carrier for next generation first-aid hemostatic study.