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Expression of brain-derived neurotrophic factor in hippocampus of ovariectomized mouse / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 53-56, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-813476
ABSTRACT
OBJECTIVE@#To explore the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus after ovariectomy in mice.@*METHODS@#BDNF levels were detected by immunohistochemistry combined image analysis in hippocampal CA regions and dentate gyrus of ovariectomized mice.@*RESULTS@#The expression of BDNF in hippocampus of mice decreased significantly after the ovariectomy after 4 days. The recovery BDNF expression started 14 days after the ovariectomy and after 28 days, the expression of BDNF in hippocampus recovered to the normal level.@*CONCLUSION@#The decrease of estrogen in ovariectomized mice can weaken the expression of BDNF in hippocampus during the early stage.